Evidence map›Paper›PMID 32324217›Full record

ArticleNucleic acids research2020

MusiteDeep: a deep-learning based webserver for protein post-translational modification site prediction and visualization.

Duolin Wang, Dongpeng Liu, Jiakang Yuchi, Fei He, Yuexu Jiang, Siteng Cai, Jingyi Li, Dong Xu

Abstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Predicting Functional Diversity Within Enzyme Families: A Practical Perspective.Chembiochem : a European journal of chemical biology · 2026
    Review
  3. Article
  4. Genome-Wide Analysis of theInternational journal of molecular sciences · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. CLASPP: A unified model for predicting post-translational modifications.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Advances and opportunities for computational interrogation of plant proteins.The Plant journal : for cell and molecular biology · 2026
    Review
  19. Article
  20. Article

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Duolin WangChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Dongpeng LiuDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.
Jiakang YuchiDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.
Fei HeChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Yuexu JiangChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Siteng CaiDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.
Jingyi LiSchool of Information Science and Technology, Northeast Normal University, Changchun, Jilin 130117, China.
Dong XuChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.

Funding

Multi-view self-supervised deep learning for biological sequences and beyondR35GM126985 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI DONG XU · 2018 to 2026
$3.8M
NIGMS NIH HHS R35 GM126985
6 · The paper itself

Abstract

MusiteDeep is an online resource providing a deep-learning framework for protein post-translational modification (PTM) site prediction and visualization. The predictor only uses protein sequences as input and no complex features are needed, which results in a real-time prediction for a large number of proteins. It takes less than three minutes to predict for 1000 sequences per PTM type. The output is presented at the amino acid level for the user-selected PTM types. The framework has been benchmarked and has demonstrated competitive performance in PTM site predictions by other researchers. In this webserver, we updated the previous framework by utilizing more advanced ensemble techniques, and providing prediction and visualization for multiple PTMs simultaneously for users to analyze potential PTM cross-talks directly. Besides prediction, users can interactively review the predicted PTM sites in the context of known PTM annotations and protein 3D structures through homology-based search. In addition, the server maintains a local database providing pre-processed PTM annotations from Uniport/Swiss-Prot for users to download. This database will be updated every three months. The MusiteDeep server is available at https://www.musite.net. The stand-alone tools for locally using MusiteDeep are available at https://github.com/duolinwang/MusiteDeep_web.

Indexed as

Deep LearningProtein Processing, Post-TranslationalSoftwareComputer GraphicsInternetModels, MolecularProtein ConformationProteinsSequence Analysis, ProteinProteins

Identifiers

PMID32324217
PMCPMC7319475

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.