Evidence map›Paper›PMID 32324136›Full record

ArticleeLife2020

Serotonin signaling by maternal neurons upon stress ensures progeny survival.

Srijit Das, Felicia K Ooi, Johnny Cruz Corchado, Leah C Fuller, Joshua A Weiner, Veena Prahlad

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. piRNAs safeguard splicing and RNA fidelity during heat shock.bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Article
  5. Neuronal IL-17 controlsProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. The Third Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The Thermal Stress Coping Network of the NematodeInternational journal of molecular sciences · 2022
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. The Second Annual Symposium of the Midwest Aging Consortium: The Future of Aging Research in the Midwestern United States.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Srijit DasDepartment of Biology, Aging Mind and Brain Initiative, Iowa City, United States.ORCID 0000-0002-0402-3256
Felicia K OoiDepartment of Biology, Aging Mind and Brain Initiative, Iowa City, United States.ORCID 0000-0003-4766-2477
Johnny Cruz CorchadoDepartment of Biology, Aging Mind and Brain Initiative, Iowa City, United States.
Leah C FullerDepartment of Biology, Iowa City, United States.
Joshua A WeinerDepartment of Biology, Iowa City, United States.ORCID 0000-0002-3352-2847
Veena PrahladDepartment of Biology, Aging Mind and Brain Initiative, Iowa City, United States.ORCID 0000-0002-0413-6074

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Elucidating Functions of the Gamma-Protocadherins in CNS Synapse DevelopmentR01NS055272 · NINDS · UNIVERSITY OF IOWA · PI WEINER, JOSHUA A · 2007 to 2020
$5.1M
Investigating how stress induced changes in maternal serotonin affect offspring development and stress resilienceR01MH126282 · NIMH · UNIVERSITY OF IOWA · PI Veena Prahlad · 2022 to 2026
$2.1M
Uncovering how serotonergic signaling non-autonomously regulates protein homeostasisR01AG050653 · NIA · UNIVERSITY OF IOWA · PI PRAHLAD, VEENA · 2016 to 2020
$1.5M
NIA NIH HHS R01 AG050653NIH HHS P40 OD010440NIMH NIH HHS R01 MH126282NINDS NIH HHS R01 NS055272
6 · The paper itself

Abstract

Germ cells are vulnerable to stress. Therefore, how organisms protect their future progeny from damage in a fluctuating environment is a fundamental question in biology. We show that in

Indexed as

AnimalsCaenorhabditis elegansCyclic AMP-Dependent Protein KinasesDNA-Binding ProteinsEmbryonic DevelopmentFemaleGene Expression Regulation, DevelopmentalGerm CellsHeat Shock Transcription FactorsHigh Mobility Group ProteinsHot TemperatureHumansMiceMice, Inbred C57BLNeuronsSerotoninCyclic AMP-Dependent Protein KinasesDNA-Binding ProteinsHeat Shock Transcription FactorsHigh Mobility Group ProteinsHSF1 protein, humanSerotoninSSRP1 protein, humanTranscriptional Elongation FactorsC. eleganscell biologycell non-autonomousepigenetichistone chaperoneHSF1neuronal signalingserotonin

Identifiers

PMID32324136
PMCPMC7237211
OpenAlexW3017836382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.