ArticleeLife2020
High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 64 citations in OpenAlex.
- A lipid-binding protein that boosts daytime wake is mainly located at the body surface and blocks light-induced lipid peroxidation in the brain.Current biology : CB · 2026Article
- Host genomic regulation of ileal Bradyrhizobium abundance modulates eating speed and fat metabolism in birds: a causal mechanism study.Journal of animal science and biotechnology · 2026Article
- Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet ineLife · 2026Article
- Starve-Feed Cycles Direct Quiescence to Proliferation Transitions inbioRxiv : the preprint server for biology · 2026Article
- High-saturated-fat diet drives female-biased neurodegeneration inFrontiers in aging neuroscience · 2026Article
- A symbiotic gene stimulates aggressive behavior favoring the survival of parasitized caterpillars.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Regular exercise ameliorates high-fat diet-induced depressive-like behaviors by activating hippocampal neuronal autophagy and enhancing synaptic plasticity.Cell death & disease · 2024Article
- Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila.Neuron · 2024Article
- Article
- Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse.Cell research · 2023Article
- Article
- Ion transport peptide regulates energy intake, expenditure, and metabolic homeostasis in Drosophila.Genetics · 2022Article
- Autism-like behaviors regulated by the serotonin receptor 5-HT2B in the dorsal fan-shaped body neurons of Drosophila melanogaster.European journal of medical research · 2022Article
- Article
- TheMolecules and cells · 2022Article
- Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila.BMC biology · 2022Article
- Phenotyping ofBiomolecules · 2022Review
- Mechanisms of Variability Underlying Odor-Guided Locomotion.Frontiers in behavioral neuroscience · 2022Review
- Sex determination geneeLife · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The function of the central nervous system to regulate food intake can be disrupted by sustained metabolic challenges such as high-fat diet (HFD), which may contribute to various metabolic disorders. Previously, we showed that a group of octopaminergic (OA) neurons mediated starvation-induced hyperactivity, an important aspect of food-seeking behavior (Yu et al., 2016). Here we find that HFD specifically enhances this behavior. Mechanistically, HFD increases the excitability of these OA neurons to a hunger hormone named adipokinetic hormone (AKH), via increasing the accumulation of AKH receptor (AKHR) in these neurons. Upon HFD, excess dietary lipids are transported by a lipoprotein LTP to enter these OA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.