Evidence map›Paper›PMID 32323565›Full record

ArticleAntioxidants & redox signaling2020

Is Low Alveolar Type II Cell

Ahmed S Abouhashem, Kanhaiya Singh, Hassan M E Azzazy, Chandan K Sen

Open access · hybridAbstract readNews
In one paragraph

Article in Antioxidants & redox signaling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  9. The vascular perspective on acute and chronic lung disease.The Journal of clinical investigation · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ahmed S AbouhashemIndiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kanhaiya SinghIndiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hassan M E AzzazyDepartment of Chemistry, School of Sciences and Engineering, The American University in Cairo, New Cairo, Egypt.
Chandan K SenIndiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Indiana University – Purdue University Indianapolis · USAmerican University in Cairo · EG

Funding

Vitamin E Neuroprotection: Novel Molecular MechanismsR01NS042617 · NINDS · OHIO STATE UNIVERSITY · PI SEN, CHANDAN K · 2002 to 2021
$3.9M
Wound Healing Endpoint and RecurrenceR01NR015676 · NINR · OHIO STATE UNIVERSITY · PI GORDILLO, GAYLE M, ROY, SASHWATI · 2015 to 2019
$2.6M
Novel Regulators of Wound AngiogenesisR01GM108014 · NIGMS · OHIO STATE UNIVERSITY · PI SEN, CHANDAN K · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM108014NINDS NIH HHS R01 NS042617NINR NIH HHS R01 NR015676
6 · The paper itself

Abstract

Human lungs single-cell RNA sequencing data from healthy donors (elderly and young; GEO accession no. GSE122960) were analyzed to isolate and specifically study gene expression in alveolar type II cells. Colocalization of angiotensin-converting enzyme 2 (

Indexed as

Activating Transcription Factor 4AdultAgedAlveolar Epithelial CellsAngiotensin-Converting Enzyme 2AntioxidantsBetacoronavirusCoronavirus InfectionsCOVID-19FemaleGene Expression RegulationHeme Oxygenase-1HumansLungMaleMetallothioneinACE2 protein, humanActivating Transcription Factor 4Angiotensin-Converting Enzyme 2AntioxidantsATF4 protein, humanHeme Oxygenase-1MetallothioneinMT2A protein, humanPeptidyl-Dipeptidase ASerine EndopeptidasesSOD3 protein, humanSuperoxide DismutaseTMPRSS2 protein, humanATF4COVID19lungROSsingle-cell RNA sequencingSOD3

Identifiers

PMID32323565
PMCPMC7307702
OpenAlexW3018489634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.