Evidence map›Paper›PMID 32323513›Full record

ArticleInternational journal of stem cells2020

Human Amniotic Epithelial Cells Affect the Functions of Neutrophils.

Razieh Alipour, Hossein Motedayyen, Nasrin Sereshki, Mitra Rafiee, Fereshteh Alsahebfosul, Abbasali Pourazar

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Palmitate and group BFrontiers in immunology · 2024
    Article
  4. Review
  5. Review
  6. Biological properties and surgical applications of the human amniotic membrane.Frontiers in bioengineering and biotechnology · 2022
    Review
  7. Perinatal derivatives: How to best characterize their multimodal functionsFrontiers in bioengineering and biotechnology · 2022
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Razieh AlipourDepartment of Immunology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Hossein MotedayyenDepartment of Immunology, Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Nasrin SereshkiDepartment of Immunology, Asadabad School of Medical Science, Asadabad, Iran.
Mitra RafieeCellular and Molecular Research Center, Department of Immunology, Medical School, Birjand University of Medical Sciences, Birjand, Iran.
Fereshteh AlsahebfosulDepartment of Immunology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Abbasali PourazarDepartment of Immunology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences · IRBirjand University of Medical Sciences · IRKashan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesAs a stem cell group, Human amniotic epithelial cells (HAECs) have numerous advantages over their embryonic and adult counterparts for therapeutic utility. They are closer to clinical applications compared to other stem cell types. Additionally, the anti-inflammatory and immunoregulatory properties of HAECs toward several immune cells have been shown previously. Nevertheless, despite the ever-increasing importance of neutrophils in the immune and non-immune processes, a few studies investigated the interaction of neutrophils and HAECs. To increase the current knowledge of HAECs immunology which is necessary for optimizing their future clinical applications, here we explored the effect of HAECs on two chief neutrophil functions; respiratory burst and phagocytosis. METHODS AND

resultsFreshly isolated human blood neutrophils were co-cultured with different number of HAECs for about 24 or 48 hours, then the oxidative burst and phagocytosis of stimulated neutrophils were assessed and compared. The results demonstrated a substantial elevation in the phagocytosis percentage, conversely a significant reduction in the oxidative burst of HAECs-cocultured neutrophils. These effects were dose-dependent, but did not show similar patterns. Likewise, the elongation of coculture period inversely influenced the HAECs-induced effects on the two neutrophil functions.

conclusionsThe present study, for the first time, investigated the HAECs-mediated effects on the two main neutrophil functions. The findings suggest that HAECs by enhancement of phagocytic ability and simultaneously, attenuation of oxidative burst capacity of neutrophils protect the fetus from both microbial treats and oxidative stress and their consequent inflammation; thus corroborate the current anti-inflammatory vision of HAECs.

Indexed as

Human amniotic epithelial cellsNeutrophilsOxidative burstPhagocytosis

Identifiers

PMID32323513
PMCPMC7378904
OpenAlexW3019568317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.