Evidence map›Paper›PMID 32323511›Full record

ArticleInternational journal of stem cells2020

Intratracheal Transplantation of Amnion-Derived Mesenchymal Stem Cells Ameliorates Hyperoxia-Induced Neonatal Hyperoxic Lung Injury via Aminoacyl-Peptide Hydrolase.

Zhenghao Li, Xiangcui Gong, Dong Li, Xiaofei Yang, Qing Shi, Xiuli Ju

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  11. COVID-19 and the role of stem cells.Regenerative therapy · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Zhenghao LiDepartment of Pediatrics, Qilu Hospital of Shandong University, Ji'nan, China.
Xiangcui GongDepartment of Pediatrics, Qingdao Women and Children's Hospital, Qingdao, China.
Dong LiStem Cell and Regenerative Medicine Research Center of Shandong University, Ji'nan, China.
Xiaofei YangDepartment of Pediatrics, Yidu Central Hospital of Weifang, Qingzhou, China.
Qing ShiStem Cell and Regenerative Medicine Research Center of Shandong University, Ji'nan, China.
Xiuli JuDepartment of Pediatrics, Qilu Hospital of Shandong University, Ji'nan, China.
Regenerative Medicine Institute · MXQilu Hospital of Shandong University · CNQingdao Women and Children's Hospital · CNShandong University · CNYidu Central Hospital of Weifang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesBronchopulmonary dysplasia (BPD) has major effects in premature infants. Although previous literature has indicated that mesenchymal stem cells (MSCs) can alleviate lung pathology in BPD newborns and improve the survival rate, few research have been done investigating significantly differentially expressed genes in the lungs before and after MSCs therapy. The aim of this study is to identify differentially expressed genes in lung tissues before and after hAD-MSC treatment. METHODS AND

resultsHuman amnion-derived MSCs (hAD-MSCs) were cultured and met the MSCs criteria for cell phenotype and multidirectional differentiation. Then we confirmed the size of hAD-MSCs-EXOs and their expressed markers. An intratracheal drip of living cells showed the strongest effect on NHLI compared to cellular secretions or exosomes, both in terms of ameliorating pulmonary edema and reducing inflammatory cell infiltration. Through gene chip hybridization, PCR, and western blotting, acylaminoacyl-peptide hydrolase (APEH) expression was found to be significantly decreased under hyperoxia, and significantly increased after hAD-MSC treatment.

conclusionsThe intratracheal transplantation of hAD-MSCs ameliorated NHLI in neonatal rats through APEH.

Indexed as

Acylaminoacyl-peptide hydrolaseBronchopulmonary dysplasiaCell therapyHuman amniotic mesenchymal stem cells

Identifiers

PMID32323511
PMCPMC7378897
OpenAlexW3018704595

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.