ArticleKorean journal of radiology2020
Thyroid Nodules with Isolated Macrocalcifications: Malignancy Risk of Isolated Macrocalcifications and Postoperative Risk Stratification of Malignant Tumors Manifesting as Isolated Macrocalcifications.
Article in Korean journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The Application of Artificial Intelligence in Thyroid Nodules: A Systematic Review Based on Bibliometric Analysis.Endocrine, metabolic & immune disorders drug targets · 2024Pooled it
- 2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS.Endocrine · 2020Guideline
- Determining malignancy in thyroid nodules featuring anterior macrocalcifications with strong posterior acoustic shadowing: the combined utility of US-FNA andQuantitative imaging in medicine and surgery · 2026Article
- Correlation between ultrasound calcification patterns, and clinicopathological factors and recurrence risk in papillary thyroid carcinoma.Gland surgery · 2025Article
- Risk Stratification of Thyroid Nodules Diagnosed as Follicular Neoplasm on Core Needle Biopsy.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Diagnostic yield of fine needle aspiration with simultaneous core needle biopsy for thyroid nodules.Journal of pathology and translational medicine · 2025Article
- The value of non-punctate echogenic foci in the ultrasonic diagnosis of thyroid nodules.Endocrine · 2025Article
- Malignant risk of thyroid nodules with isolated macrocalcifications - A study based on surgery results.Clinics (Sao Paulo, Brazil) · 2025Article
- Application research of artificial intelligence software in the analysis of thyroid nodule ultrasound image characteristics.PloS one · 2025Article
- Risk Stratification of Thyroid Nodules Diagnosed as Bethesda Category III by Ultrasound, Size, and Cytology.Korean journal of radiology · 2024Observational
- Deep learning approaches for differentiating thyroid nodules with calcification: a two-center study.BMC cancer · 2023Article
- [Clinical Application of the 2021 Korean Thyroid Imaging Reporting and Data System (K-TIRADS)].Journal of the Korean Society of Radiology · 2023Review
- Role of echogenic foci in ultrasonographic risk stratification of thyroid nodules: Echogenic focus scoring in the American College of Radiology Thyroid Imaging Reporting and Data System.Frontiers in oncology · 2022Article
- Article
- 2021 Korean Thyroid Imaging Reporting and Data System and Imaging-Based Management of Thyroid Nodules: Korean Society of Thyroid Radiology Consensus Statement and Recommendations.Korean journal of radiology · 2021Review
- Comparison of the diagnostic performance of the modified Korean Thyroid Imaging Reporting and Data System for thyroid malignancy with three international guidelines.Ultrasonography (Seoul, Korea) · 2021Article
- Korean Thyroid Imaging Reporting and Data System: Current Status, Challenges, and Future Perspectives.Korean journal of radiology · 2021Review
- Different sonographic features of peripheral thyroid nodule calcification and risk of malignancy: a prospective observational study.Polish journal of radiology · 2021Article
- Clinical significance of isolated macrocalcifications detected by ultrasonography.Ultrasonography (Seoul, Korea) · 2020Article
- Re: Clinical significance of isolated macrocalcifications detected by ultrasonography.Ultrasonography (Seoul, Korea) · 2020Article
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7 authors at 1 institution in 1 country.
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Abstract
objectiveTo determine the malignancy risk of isolated macrocalcifications (a calcified nodule with complete posterior acoustic shadowing) detected on ultrasonography (US) and to evaluate the postoperative American Thyroid Association (ATA) risk stratification of malignant tumors manifesting as isolated macrocalcifications. MATERIALS AND
methodsA total of 3852 thyroid nodules (≥ 1 cm) of 3061 consecutive patients who had undergone biopsy between January 2011 and June 2018 were included in this study. We assessed the prevalence, malignancy rate, and size distribution of isolated macrocalcifications and evaluated the histopathologic features and postoperative ATA risk stratification of malignant tumors manifesting as isolated macrocalcifications.
resultsIsolated macrocalcifications were found in 38 (1.2%) of the 3061 patients. Final diagnosis was established in 30 (78.9%) nodules; seven malignant tumors were diagnosed as papillary thyroid carcinomas (PTCs). The malignancy rate of the isolated macrocalcifications was 23.3% in the 30 nodules with final diagnoses and 18.4% in all nodules. Among the six surgically-treated malignant tumors, five (83.3%) had an extrathyroidal extension (ETE) (minor ETE 1, gross ETE 4), and two (33.3%) had macroscopic lymph node metastasis. Four (66.7%) malignant tumors were categorized as high-risk tumors, one as an intermediate-risk tumor, and one as a low-risk tumor using the ATA risk stratification. Histopathologically, out of the six malignant tumors, ossifications were noted in four (66.7%) and predominant calcifications in two (33.3%).
conclusionThe US pattern of isolated macrocalcifications (≥ 1 cm) showed an intermediate malignancy risk (at least 18.4%). All malignant tumors were PTCs, and most showed an aggressive behavior and a high or intermediate postoperative ATA risk.
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