ArticleInternational journal for numerical methods in biomedical engineering2020
Fluid flow-induced cell stimulation in bone tissue engineering changes due to interstitial tissue formation in vitro.
Article in International journal for numerical methods in biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Predicting Cell Differentiation in Mechanically Stimulated Biphasic Osteochondral Scaffolds Using Fluid-Structure Interaction Modelling.Bioengineering (Basel, Switzerland) · 2026Article
- A Fluid Dynamics-Model System for Advancing Tissue Engineering and Cancer Research Studies: Biological Assessment of the Innovative BioAxFlow Dynamic Culture Bioreactor.Biomimetics (Basel, Switzerland) · 2025Article
- Numerical study of the structural design influence on cartilage cell differentiation in mechanically stimulated hydrogel scaffolds using an FSI-based model.Biomechanics and modeling in mechanobiology · 2025Article
- Flow performance of porous implants with different geometry: Line, surface, and volume structures.International journal of bioprinting · 2023Article
- Simulating the mechanical stimulation of cells on a porous hydrogel scaffold using an FSI model to predict cell differentiation.Frontiers in bioengineering and biotechnology · 2023Article
- Wall Shear Stress Analysis and Optimization in Tissue Engineering TPMS Scaffolds.Materials (Basel, Switzerland) · 2022Article
- Bioengineered Living Bone Grafts-A Concise Review on Bioreactors and Production Techniques In Vitro.International journal of molecular sciences · 2022Review
- Challenges in computational fluid dynamics applications for bone tissue engineering.Proceedings. Mathematical, physical, and engineering sciences · 2022Review
- Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021Review
- Fluid flow-induced cell stimulation in bone tissue engineering changes due to interstitial tissue formation in vitro.International journal for numerical methods in biomedical engineering · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In tissue engineering experiments in vitro, bioreactors have been used for applying wall shear stress (WSS) on cells to regulate cellular activities. To determine the loading conditions within bioreactors and to design tissue engineering products, in silico models are used. Previous in silico studies in bone tissue engineering (BTE) focused on quantifying the WSS on cells and the influence on appositional tissue growth. However, many BTE experiments also show interstitial tissue formation (i.e., tissue infiltrated in the pores rather than growing on the struts - appositional growth), which has not been considered in previous in silico studies. We hereby used a multiscale fluid-solid interaction model to quantify the WSS and mechanical strain on cells with interstitial tissue formation, taken from a reported BTE experiment. The WSS showed a high variation among different interstitial tissue morphologies. This is different to the situation under appositional tissue growth. It is found that a 35% filling of the pores results (by mineralised bone tissue) when the average WSS increases from 1.530 (day 0) to 5.735 mPa (day 28). Furthermore, the mechanical strain on cells caused by the fluid flow was extremely low (at the level of 10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.