Evidence map›Paper›PMID 32323203›Full record

Trial reportNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2020

Anterior Cingulate Cortex Implants for Alcohol Addiction: A Feasibility Study.

Sook Ling Leong, Paul Glue, Patrick Manning, Sven Vanneste, Louisa Joyce Lim, Anusha Mohan, Dirk De Ridder

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Pooled it
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  12. Deep Brain Stimulation for Addictive Disorders-Where Are We Now?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Sook Ling LeongTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. sookling.leong@tcd.ie.
Paul GlueDepartment of Psychological Medicine, University of Otago, Dunedin, New Zealand.
Patrick ManningDepartment of Medicine, University of Otago, Dunedin, New Zealand.
Sven VannesteTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Louisa Joyce LimDepartment of Surgical Sciences, University of Otago, Dunedin, New Zealand.
Anusha MohanTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Dirk De RidderDepartment of Surgical Sciences, University of Otago, Dunedin, New Zealand. dirk.deridder@otago.ac.nz.
University of Otago · NZTrinity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal neural activity, particularly in the rostrodorsal anterior cingulate cortex (rdACC), appears to be responsible for intense alcohol craving. Neuromodulation of the rdACC using cortical implants may be an option for individuals with treatment-resistant alcohol dependence. This study assessed the effectiveness and feasibility of suppressing alcohol craving using cortical implants of the rdACC using a controlled one-group pre- and post-test study design. Eight intractable alcohol-dependent participants (four males and four females) were implanted with two Lamitrode 44 electrodes over the rdACC bilaterally connected to an internal pulse generator (IPG). The primary endpoint, self-reported alcohol craving reduced by 60.7% (p = 0.004) post- compared to pre-stimulation. Adverse events occurred in four out of the eight participants. Electrophysiology findings showed that among responders, there was a post-stimulation decrease (p = 0.026) in current density at the rdACC for beta 1 band (13-18 Hz). Results suggest that rdACC stimulation using implanted electrodes may potentially be a feasible method for supressing alcohol craving in individuals with severe alcohol use disorder. However, to further establish safety and efficacy, larger controlled clinical trials are needed.

Indexed as

Electrodes, ImplantedAdultAlcoholismElectroencephalographyFeasibility StudiesFemaleGyrus CinguliHumansMaleMiddle AgedTranscranial Magnetic StimulationAlcohol cravingAlcohol dependenceAnterior cingulate cortexCortical stimulation

Identifiers

PMID32323203
PMCPMC7641294
OpenAlexW3017605535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.