ArticleBiological trace element research2021
The Association Between Trace Elements Exposure and the Cognition in the Elderly in China.
Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Plasma Metal Concentration is Sex Dependent and Associated with Fragility Fractures: Results of METOSTEO Cohort.Biological trace element research · 2026Article
- Magnesium Attenuates the Association Between Mixed Element Exposure and Depressive Symptoms in Older Adults.Toxics · 2026Article
- Arsenic Trioxide Underpins Delayed Neuroinflammation and Impaired Synaptic Integrity involving Integrative Stress Response Signaling.bioRxiv : the preprint server for biology · 2025Article
- Association of dietary intake and whole blood essential trace elements with frailty in older adults: a cross-sectional study.Aging clinical and experimental research · 2025Article
- Trace elements and cognitions in elderly population: a case-control study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Epidemiological Evidence on the Associations of Metal Exposure with Alzheimer's Disease and Related Dementias Among Elderly Women.Journal of clinical medicine · 2025Review
- Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.Frontiers in pediatrics · 2025Article
- Blood essential trace elements and Alzheimer's disease biomarkers in midlife.Frontiers in aging neuroscience · 2025Article
- Exposure to Cadmium and Other Trace Elements Among Individuals with Mild Cognitive Impairment.Toxics · 2024Article
- Effects of PMEnvironment & health (Washington, D.C.) · 2024Article
- Multi-element Exposure and Cognitive Function in Rural Elderly Chinese.Biological trace element research · 2024Article
- Associations between plasma metal elements and risk of cognitive impairment among Chinese older adults.Frontiers in aging neuroscience · 2024Article
- Association Between the Ratios of Selenium to Several Elements and Mild Cognitive Impairment in the Elderly.Biological trace element research · 2023Article
- Revisiting the Role of Vitamins and Minerals in Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Associations among drinking water quality, dyslipidemia, and cognitive function for older adults in China: evidence from CHARLS.BMC geriatrics · 2022Article
- Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh.Environment international · 2022Article
- Associations Between Plasma Metals and Cognitive Function in People Aged 60 and Above.Biological trace element research · 2022Article
- Determination of aluminum concentrations in biological specimens: application in the clinical laboratory.Advances in laboratory medicine · 2022Article
- Trace Element Concentration and Cognitive Dysfunction in Elderly Residents in Birjand.Current Alzheimer research · 2022Article
- Relationships between urinary metals concentrations and cognitive performance among U.S. older people in NHANES 2011-2014.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
This study aimed to evaluate the association between aluminum (Al), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), selenium (Se), strontium (Sr), thallium (Tl), and vanadium (V) levels in whole blood and the cognitive ability of people over 60 years old. A total of 1217 eligible participants were enrolled in our study in Lu'an city, Anhui province, China. The inductively coupled plasma mass spectrometry (ICP-MS) was used to determine the concentration of nine trace elements in the whole blood, which reflect their exposure levels. Mini-mental State Examination (MMSE) scale was employed to screen the cognitive function of the elderly. Logistic regression was applied to assess the associations of nine whole blood trace elements with cognition. In the work, it has found that high levels of whole blood As and Se are risk factors for cognitive dysfunction. As and Se quartile were correlated with increased risk of cognitive dysfunction, and with the odds ratio (OR) of 2.06 (95% CI 1.30-3.25; p-trend = 0.002), 1.947 (95% CI 1.20-3.17; p-trend = 0.007) in the highest quartile. However, high concentration of Al, V, and Ba in whole blood were protective factors for cognitive function [OR = 0.63 (95% CI 0.40-0.98; p-trend = 0.040), 0.549 (95% CI 0.36-0.85; p-trend = 0.007), 0.460 (95% CI 0.28-0.75; p-trend = 0.002) respectively]. The study suggested that the exposure of some trace elements (As, Se) were associated with the increased risk of cognitive dysfunction; on the contrary, other elements (Al, V, Ba) could be protective factor for cognitive function. These findings need to be confirmed in additional research of a large elderly population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.