ArticleBrain imaging and behavior2021
Abnormal large-scale resting-state functional networks in drug-free major depressive disorder.
Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Development of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model of Psilocybin/Psilocin from Psilocybe cubensis (Magic Mushroom) in Treatment-Resistant Depression.European journal of drug metabolism and pharmacokinetics · 2026Article
- Unraveling spatiotemporal dynamics in transdiagnosis subtypes of major depressive disorder and bipolar disorder: insights from co-activation patterns and treatment response.Molecular psychiatry · 2026Article
- A Study on dynamic functional connectivity and efficacy prediction of SAINT for rapid antidepressant effects and relief of suicidal ideation.Translational psychiatry · 2025Article
- Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a large-scale resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder.BMC psychiatry · 2024Article
- The overlap across psychotic disorders: A functional network connectivity analysis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- Prediction of Early Antidepressant Efficacy in Patients with Major Depressive Disorder Based on Multidimensional Features of rs-fMRI andCanadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- The neural signature of psychomotor disturbance in depression.Molecular psychiatry · 2024Article
- Enhanced rich club connectivity in mild or moderate depression after nonpharmacological treatment: A preliminary study.Brain and behavior · 2023Article
- Addressing multi-site functional MRI heterogeneity through dual-expert collaborative learning for brain disease identification.Human brain mapping · 2023Article
- Article
- Unsupervised cross-domain functional MRI adaptation for automated major depressive disorder identification.Medical image analysis · 2023Article
- Altered spatio-temporal state patterns for functional dynamics estimation in first-episode drug-naive major depression.Brain imaging and behavior · 2022Article
- Characterization of Resting-State Striatal Differences in First-Episode Depression and Recurrent Depression.Brain sciences · 2022Article
- Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode.International journal of environmental research and public health · 2022Article
- Aberrant brain connectivity is associated with childhood maltreatment in individuals with major depressive disorder.Brain imaging and behavior · 2022Article
- Resting-state functional connectivity of salience network in schizophrenia and depression.Scientific reports · 2022Article
- Functional MRI in major depressive disorder: A review of findings, limitations, and future prospects.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Review
- Decreased modular segregation of the frontal-parietal network in major depressive disorder.Frontiers in psychiatry · 2022Article
- Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence.International journal of general medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Major depressive disorder (MDD) is associated with aberrant function and interaction encompassing large parts of cortical, subcortical and limbic regions that always organized into integrative networks implicated in specific tasks. And cumulative evidence suggests that MDD can be understood as a disorder of dysregulated network. Our study used resting-state fMRI and independent component analysis (ICA) to investigate intrinsic functional connectivity (FC) within and between resting-state networks (RSNs) in 27 drug-free MDD patients and 54 healthy control subjects (HCs). Granger causality analysis (GCA) was further used to identify the direct functional interaction between RSNs. We identified sixteen independent components (ICs) as meaningful RSNs. Compared with HCs, the MDD had significantly decreased intra-FC within lateral visual network (VN), parietal network (PN) and posterior default mode network (pDMN), decreased inter-FC between fronto-parietal network (FPN) and subcortical network, between pDMN and anterior DMN, and increased inter-FC between salience network and FPN, and enhanced effective connectivity from VN to PN and to cerebellum network. The functional synchronization of pDMN was negatively correlated with Hamilton Depression Rating Scores. The relatively small number of MDD, the use of medication and the application challenges of GCA on fMRI data may limit the interpretability. These findings indicated that MDD is indeed a disorder of dysregulated network, especially in the functional networks implicated in self-referential activities and emotional visual processing.
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