SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
Sensory stimulation to improve arousal in comatose patients after traumatic brain injury: a systematic review of the literature.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07544602 (Music Therapy for Comatose Brain Injured Patients), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Music Therapy for Comatose Brain Injured Patients
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Best Evidence Summary for the Improvement and Management of Disorders of Consciousness in Patients With Severe Brain Injury.Brain and behavior · 2025Pooled it
- Efficacy of Multimodal Sensory Therapy in Adult Acquired Brain Injury: A Systematic Review.Neuropsychology review · 2023Pooled it
- Review
- Effect of Auditory and Tactile Stimulation on the Level of Consciousness and Physiological Parameters in ICU Patients With Altered Consciousness.Critical care research and practice · 2026Article
- An Early Rehabilitation Favors the Prognosis of Hypertensive Intracerebral Hemorrhage With Acute Disorders of Consciousness: A Retrospective Cohort Study With Propensity Score Matching.Neural plasticity · 2025Article
- Neurophysiological and Psychometric Outcomes in Minimal Consciousness State after Advanced Audio-Video Emotional Stimulation: A Retrospective Study.Brain sciences · 2023Article
- Investigating the effect of implementing a sensory stimulation program by family members on delirium status of brain injury patients hospitalized in the intensive care unit: A randomized clinical trial.Journal of education and health promotion · 2023Article
- Effect of integrated perioperative rehabilitation intervention under the fast-track surgery concept on stress and complications in patients undergoing craniocerebral injury surgery.Frontiers in surgery · 2022Article
- Impact of a sensory stimulation program conducted by family members on the consciousness and pain levels of ICU patients: A mixed method study.Frontiers in medicine · 2022Article
- Effect of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Hyperbaric Oxygen (HBO) on Awakening of Coma Patients with Traumatic Brain Injury.Journal of healthcare engineering · 2022Article
- Article
- Intensive Care Admission and Early Neuro-Rehabilitation. Lessons for COVID-19?Frontiers in neurology · 2020Review
- Effectiveness of coma arousal therapy on patients with disorders of consciousness - A systematic review and meta-analysis.Brain circulationReview
- The application of optogenetics in traumatic brain injury research: A narrative review.Brain circulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo standard rehabilitative treatment for coma arousal after traumatic brain injury (TBI) exists. Based on our clinical experience, we hypothesized that sensory stimulation (SS) is a promising protocol to improve outcomes in these patients.
methodsWe performed a literature review on the progress of sensory stimulation to enhance coma arousal after traumatic brain injury. We searched the databases on Medline, Embase, and Cochrane to gain access to relevant publications using the key words "traumatic brain injury," "disorders of consciousness," "sensory stimulation," and "coma scale."
resultsWe included all original studies published in English with patients presenting severe disorders of consciousness due to traumatic brain injury who had received SS and whose behavioral/neural responses had been measured. We compared data on ten selected studies and analyzed the SS effects in comatose patient outcomes after TBI. Our review outlines the role of SS in patients with TBI and provides guidance for its implementation in the clinical practice.
conclusionsThe literature suggests the SS program improves coma arousal after TBI. However, high-quality clinical trials are needed to establish standard SS protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.