Evidence map›Paper›PMID 32323040›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2020

High myopic patients with and without foveoschisis: morphological and functional characteristics.

Marcella Nebbioso, Alessandro Lambiase, Magda Gharbiya, Alice Bruscolini, Ludovico Alisi, Vincenza Bonfiglio

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Electroretinogram responses in myopia: a review.Documenta ophthalmologica. Advances in ophthalmology · 2022
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marcella NebbiosoDepartment of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, Rome, Italy.
Alessandro LambiaseDepartment of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, Rome, Italy. alessandro.lambiase@uniroma1.it.ORCID 0000-0002-8974-991X
Magda GharbiyaDepartment of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, Rome, Italy.
Alice BruscoliniDepartment of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, Rome, Italy.
Ludovico AlisiDepartment of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, Rome, Italy.
Vincenza BonfiglioDepartment of Ophthalmology, University of Catania, Via S. Sofia 76, 95100, Catania, Italy.
Sapienza University of Rome · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMyopic foveoschisis (MF) is characterized by the splitting of the retinal layers in the fovea of patients with high myopia (HM). MF may progress into foveal detachment or macular hole formation with consequent loss of central vision. The aim of this study is to investigate morphological and functional changes of the macular region in myopic subjects with and without foveoschisis.

designObservational, cross-sectional, comparative study.

methodsForty-eight patients with HM and 24 healthy controls were evaluated by spectral domain-optical coherence tomography (SD-OCT), multifocal electroretinography (mfERG) and microperimetry (MP-1) tests to assess macular thickness, functionality and sensitivity values, respectively. The results of the diagnostic examinations were compared between three groups: HM patients with MF (N = 24), HM patients without MF (N = 24) and control group (CG) (N = 24). All statistical analyses were performed with STATA 14.0 (Collage Station, Texas, USA). One-way analysis of variance (ANOVA) followed by Tukey's post hoc test was used to analyze differences between groups unless specified; p values < 0.05 were considered as statistically significant. Gender distribution was compared by the Chi square test.

resultsThe statistical analysis with one-way ANOVA followed by Tukey's post hoc test showed a significant increase in macular thickness in HM patients with MF when compared to both HM patients without MF and CG. Morphological changes were associated with functional impairment as demonstrated by the significant decrease in amplitude of the P1 wave and MP-1 sensitivity (p < 0.05), according to the anatomical landmarks.

conclusionsThis study showed that the morphological changes observed in the central retina of HM patients with MF are associated with functional alterations. High-tech diagnostic tests such as SD-OCT, mfERG and MP-1 could be useful for management in complications of MF.

Indexed as

Cross-Sectional StudiesElectroretinographyFemaleFovea CentralisHumansMaleMiddle AgedMyopia, DegenerativeRetinaRetinal PerforationsRetinoschisisTomography, Optical CoherenceVisual AcuityVisual FieldsVisual Field TestsVitrectomyHigh myopiaMicroperimetry (MP-1)Multifocal electroretinography (mfERG)Myopic foveoschisisPathological myopiaRetinoschisisSpectral domain-optical coherence tomography (SD-OCT)

Identifiers

PMID32323040
OpenAlexW3017625196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.