Evidence map›Paper›PMID 32322929›Full record

ArticleExperimental brain research2020

Effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation.

Shady Safwat Hassan, Carlos Trenado, Tarek Ali Rageh, Alfons Schnitzler, Stefan Jun Groiss

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Shady Safwat HassanInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.ORCID https://orcid.org/0000-0002-9178-8344
Carlos TrenadoInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Tarek Ali RagehDepartment of Neurology, Assiut University Hospital, Assiut, Egypt.
Alfons SchnitzlerInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Stefan Jun GroissInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. groiss@uni-duesseldorf.de.
Heinrich Heine University Düsseldorf · DEAssiut University · EGTU Dortmund University · DE

Funding

Deutsche Forschungsgemeinschaft SFB 974Deutscher Akademischer Austauschdienst 57030312
6 · The paper itself

Abstract

Cortical facilitation assessed with triad conditioning transcranial magnetic stimulation has been termed triad-conditioned facilitation (TCF). TCF has been supposed to reflect increased intracortical facilitation (ICF) at short interstimulus intervals (ISI) around 10 ms and an intrinsic rhythm of the motor cortex at longer ISI around 25 ms. To gain further insight into the pathophysiological mechanism of TCF, we systematically studied the effect of suprathreshold conditioning stimulus (CS) and test stimulus (TS) intensity on TCF. Various CS intensities and TS intensities were used in a triad-conditioning paradigm that was applied to 11 healthy subjects. ISI between pulses were studied between 5 and 200 ms. TCF at 10 ms ISI enhanced with increasing CS intensity but decreased with increasing TS intensity. The duration of facilitation was longer with higher CS intensity. However, TCF at 25 ms ISI could not be elicited with none of the CS and TS intensities addressed here. Our results are consistent with the notion of TCF at short ISI reflecting ICF. The enhanced and prolonged facilitation with increase of CS without additional isolated facilitation at longer ISI suggest a prolongation of ICF.

Indexed as

AdultConditioning, ClassicalCortical ExcitabilityElectromyographyEvoked Potentials, MotorFemaleHumansMaleMiddle AgedMuscle, SkeletalTranscranial Magnetic StimulationYoung AdultConditioning stimulus (CS)Interstimulus intervals (ISI)Motor-evoked potentials (MEP)Test stimulus (TS)Transcranial magnetic stimulation (TMS)Triad-conditioning facilitation (TCF)

Identifiers

PMID32322929
PMCPMC7237525
OpenAlexW3017535318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.