Evidence map›Paper›PMID 32322915›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Reliable quantification of

Ralph Buchert, Meike Dirks, Christian Schütze, Florian Wilke, Martin Mamach, Ann-Katrin Wirries, Henning Pflugrad, Linda Hamann, Laura B N Langer, Christian Wetzel and 10 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Kinetic modeling of the monoamine oxidase-B radioligand [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  2. Article
  3. Review
  4. Comparison of Invasive and Non-invasive Estimation of [Molecular imaging and biology · 2022
    Article
  5. Article
  6. Reduced Acquisition Time [Frontiers in medicine · 2022
    Article
  7. NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  8. TSPO imaging in animal models of brain diseases.European journal of nuclear medicine and molecular imaging · 2021
    Review
  9. Article
  10. Article
  11. In response to: Anatomy ofEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Ralph BuchertDepartment of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. r.buchert@uke.de.ORCID https://orcid.org/0000-0002-0945-0724
Meike DirksDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Christian SchützeDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Florian WilkeDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Martin MamachDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Ann-Katrin WirriesDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Henning PflugradDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Linda HamannDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Laura B N LangerDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Christian WetzelDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Mario LukacevicDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Andras PolyakDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Mariella KesslerDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Carlotta PetruschDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Frank M BengelDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Lilli GeworskiDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Rainer RupprechtDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Karin WeissenbornDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Tobias L RossDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Georg BerdingDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DEUniversity of Regensburg · DEUniversität Hamburg · DE

Funding

Deutsche Forschungsgemeinschaft 01EO1302Deutsche Forschungsgemeinschaft 422182557
6 · The paper itself

Abstract

purposeTracer kinetic modeling of tissue time activity curves and the individual input function based on arterial blood sampling and metabolite correction is the gold standard for quantitative characterization of microglia activation by PET with the translocator protein (TSPO) ligand

methodsDynamic

resultsCorrelation with the reference V

conclusionThese results support the use of a population-based input function scaled with a single blood sample or the ROI-to-whole-blood ratio at a late time point for simplified quantitative analysis of

Indexed as

BrainPositron-Emission TomographyCarbazolesHumansReceptors, GABAReproducibility of ResultsCarbazolesGE-180Receptors, GABATSPO protein, humanFlutriciclamideGE-180Input functionKinetic analysisPopulation-basedTranslocator protein (TSPO)

Identifiers

PMID32322915
PMCPMC7651670
OpenAlexW3018267488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.