Evidence map›Paper›PMID 32322711›Full record

ArticleHeliyon2020

Glymphatic clearance of simulated silicon dispersion in mouse brain analyzed by laser induced breakdown spectroscopy.

Muhammad Shehzad Khan, Rachit Kumar, Sinai H C Manno, Irfan Ahmed, Alan Wing Lun Law, Raul R Cruces, Victor Ma, William C Cho, Shuk Han Cheng, Condon Lau

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Muhammad Shehzad KhanDepartment of Physics, City University of Hong Kong, Kowloon, HKSAR, China.
Rachit KumarWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Sinai H C MannoDepartment of Physics, City University of Hong Kong, Kowloon, HKSAR, China.
Irfan AhmedElectrical Engineering Department, Sukkur IBA University, Sukkur 65200, Sindh, Pakistan.
Alan Wing Lun LawDepartment of Physics, City University of Hong Kong, Kowloon, HKSAR, China.
Raul R CrucesMcConnell Brain Imaging Center, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Victor MaDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, HKSAR, China.
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, HKSAR, China.
Shuk Han ChengDepartment of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, HKSAR, China.
Condon LauDepartment of Physics, City University of Hong Kong, Kowloon, HKSAR, China.
City University of Hong Kong · HKQueen Elizabeth Hospital · CNGeorgia Institute of Technology · USMontreal Neurological Institute and Hospital · CASukkur IBA University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silicon-based devices, such as neural probes, are increasingly used as electrodes for receiving electrical signals from neural tissue. Neural probes used chronically have been known to induce inflammation and elicit an immune response. The current study detects and evaluates silicon dispersion from a concentrated source in the mouse brain using laser induced breakdown spectroscopy. Element lines for Si (I) were found at the injection site at approximately 288 nm at 3hr post-implantation, even with tissue perfusion, indicating possible infusion into neural tissue. At 24hr and 1-week post-implantation, no silicon lines were found, indicating clearance. An isolated immune response was found by CD68 macrophage response at 24hr post injection. Future studies should measure chronic silicon exposure to determine if the inflammatory response is proportional to silicon administration. The present type of protocol, coupling laser induced breakdown spectroscopy, neuroimaging, histology, immunohistochemistry, and determination of clearance could be used to investigate the glymphatic system and different tissue states such as in disease (e.g. Alzheimer's).

Indexed as

BiophysicsElectrodeImmune responseInflammationNeuroscienceOpticsPhysicsPhysics methodsProbeSiliconToxicology

Identifiers

PMID32322711
PMCPMC7168738
OpenAlexW3017363622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.