ArticleInternational journal of cardiology. Heart & vasculature2020
Elevated plasma homocysteine levels are associated with impaired peripheral microvascular vasomotor response.
Article in International journal of cardiology. Heart & vasculature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Association of Homocysteine with Arterial Stiffness and Kidney Injury Biomarkers in Patients with Suspected Coronary Artery Disease.Journal of clinical medicine · 2026Article
- Association between peripheral and coronary microvascular function and the impact of myocardial bridging.Physiological reports · 2025Article
- A retrospective cohort study of H-type hypertension and its influence on the prognostic effect in patients with non-dialysis CKD.Frontiers in nutrition · 2025Article
- Elevated homocysteine level as an indicator for chronic kidney disease in community-dwelling middle-aged and elderly populations in Taiwan: A community-based cross-sectional study.Frontiers in medicine · 2022Article
- Homocysteine, hypertension, and risks of cardiovascular events and all-cause death in the Chinese elderly population: a prospective study.Journal of geriatric cardiology : JGC · 2021Article
- Impact of Peripheral Microvascular Endothelial Dysfunction on White Matter Hyperintensity.Journal of the American Heart Association · 2021Article
- Homocysteine predicts vascular target organ damage in hypertension and may serve as guidance for first-line antihypertensive therapy.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Classical homocystinuria, is it safe to exercise?Molecular genetics and metabolism reports · 2021Article
- Homocysteine in Neurology: A Possible Contributing Factor to Small Vessel Disease.International journal of molecular sciences · 2021Review
- Coronary Microvascular Endothelial Dysfunction in Patients With Angina and Nonobstructive Coronary Artery Disease Is Associated With Elevated Serum Homocysteine Levels.Journal of the American Heart Association · 2020Article
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Authors and funding
9 authors.
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Abstract
backgroundHyperhomocysteinemia (HHcy) has been proposed as an important cardiovascular risk factor (cRF). However, little is known about the association between plasma homocysteine levels and peripheral microvascular endothelial dysfunction (PMED), which is an integrated index of vascular health.
methodsThis cross-sectional and retrospective cohort study included patients who underwent non-invasive PMED assessment using reactive hyperemia peripheral arterial tonometry (RH-PAT). The association between HHcy and PMED, and its impact on MACE (all-cause mortality and atherosclerotic cardiovascular events) was investigated.
resultsA total of 257 patients were enrolled (HHcy > 10.0 µmol/L, N = 51; lower levels of homocysteine [LHcy] ≤ 10 µmol/L, N = 206). Patients with HHcy were older, predominantly males, and with more comorbidities than patients with LHcy (
conclusionHHcy was independently associated with PMED after adjusting for cRF and B-vitamins supplementation. Thus, the link between homocysteine and MACE could be mediated by endothelial dysfunction, and will require further clarification with future studies.
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