ArticleBone reports2020
Nonlinear voxel-based finite element model for strength assessment of healthy and metastatic proximal femurs.
Article in Bone reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Integrating serial block-face SEM with voxel-based finite element analysis for high-fidelity micromechanical modelling of anisotropic soft tissues: application to human dermis.Biomechanics and modeling in mechanobiology · 2026Article
- Importance of Metastatic Lesion Location and Subject-Specificity in the Determination of Femoral Fracture Risk.International journal for numerical methods in biomedical engineering · 2026Article
- Functionally Graded Lattice (FGL) Models for Predicting the Mechanical Properties of Femur Spongy Bone.Biomedical engineering and computational biology · 2026Article
- Customized osteosynthesis plates for multi-species fractures using ICP and TPS: an integrated CT imaging and computational modeling framework.Frontiers in veterinary science · 2025Article
- Internal validation of modified Mirels' scoring system for pathologic femur fractures.BMC musculoskeletal disorders · 2024Article
- Finite element models with automatic computed tomography bone segmentation for failure load computation.Scientific reports · 2024Article
- Modification to Mirels scoring system location component improves fracture prediction for metastatic disease of the proximal femur.BMC musculoskeletal disorders · 2023Article
- Finite Element Model-Computed Mechanical Behavior of Femurs with Metastatic Disease Varies Between Physiologic and Idealized Loading Simulations.Biomedical engineering and computational biology · 2023Article
- Experimental validation of a voxel-based finite element model simulating femoroplasty of lytic lesions in the proximal femur.Scientific reports · 2022Article
- Finite Element Assessment of Bone Fragility from Clinical Images.Current osteoporosis reports · 2021Review
- Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect.Scientific reports · 2021Article
- Can Patient-specific Finite Element Models Enter Clinical Practice as a Decision Support System?The archives of bone and joint surgery · 2021Article
- Post-operative fracture risk assessment following tumor curettage in the distal femur: a hybrid in vitro and in silico biomechanical approach.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Nonlinear finite element (FE) models can accurately quantify bone strength in healthy and metastatic femurs. However, their use in clinical practice is limited since state-of-the-art implementations using tetrahedral meshes involve a lot of manual work for which specific modelling software and engineering knowledge are required. Voxel-based meshes could enable the transition since they are robust and can be highly automated. Therefore, the aim of this work was to bridge the modelling gap between the tetrahedral and voxel-based approach. Specifically, we validated a nonlinear voxel-based FE method relative to experimental data from 20 femurs with and without artificial metastases that had been mechanically loaded until failure. CT scans of the femurs were segmented and automatically converted into a voxel-based mesh with hexahedral elements. Nonlinear material properties were implemented in an open-source linear voxel-based FE solver by adding an additional loop to the routine such that the material properties could be adapted after each increment. Bone strength, quantified as the maximum force in the force-displacement curve, was evaluated. The results were compared to a previously established nonlinear tetrahedral FE approach as well as to the experimentally measured bone strength. The voxel-based FE model predicted the experimental bone strength very well both for healthy (R
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