Evidence map›Paper›PMID 32322375›Full record

ArticleIranian journal of microbiology2020

Toxin A and B genes expression of

Mohammad Moradi, Shahla Mansouri, Nouzar Nakhaee, Farhad Sarafzadeh, Ebrahim Rezazadeh Zarandi

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mohammad MoradiDepartment of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Shahla MansouriDepartment of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Nouzar NakhaeeDepartment of Community Medicine, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Farhad SarafzadehDepartment of Infectious Diseases, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Ebrahim Rezazadeh ZarandiImmunology of Infection of Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Kerman University of Medical Sciences · IRRafsanjan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesAntibiotics prescribed for infections have diverse effects on microbiota and the pathogen MATERIALS AND

methodsThe MIC and fractional inhibitory concentration (FIC) of two

resultsAll antibiotics except CAZ (alone and in combination) decreased the gene expression of toxins A and B within 24 hours. VAN and CLI reduced toxin gene expression within 24 and 48 hours. However, CAZ alone and in combination with VAN as well as CLI increased the gene expression of toxins A and B.

conclusionThe results confirmed toxin gene transcription and toxin production are associated with the type of isolates and antibiotics, as well as the combined form of antibiotics. This could be the reason which can explain the occurrence of

Indexed as

AntibioticsClostridium difficileGene expressionToxin

Identifiers

PMID32322375
PMCPMC7163043
OpenAlexW3011429666

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.