Evidence map›Paper›PMID 32322252›Full record

ArticleFrontiers in immunology2020

Analysis of Mrgprb2 Receptor-Evoked Ca

Volodymyr Tsvilovskyy, Alejandra Solis-Lopez, Julia Almering, Christin Richter, Lutz Birnbaumer, Alexander Dietrich, Marc Freichel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Mast cell-sensory neuron crosstalk in allergic diseases.The Journal of allergy and clinical immunology · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Metabolic Consequences of IgE- and Non-IgE-Mediated Mast Cell Degranulation.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Volodymyr TsvilovskyyPharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Alejandra Solis-LopezPharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Julia AlmeringPharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Christin RichterPharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Lutz BirnbaumerNeurobiology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, United States.
Alexander DietrichWalther-Straub Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Munich, Germany.
Marc FreichelPharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Heidelberg University · DELudwig-Maximilians-Universität München · DEPontificia Universidad Católica Argentina · AR

Funding

Transmembrane Signaling Mechanisms Involving TRP ChannelsZ01ES101684 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$2.1M
Intramural NIH HHS Z01 ES101684
6 · The paper itself

Abstract

Mast cells are a heterogeneous group of immune cells. The simplest and commonly accepted classification divides them in two groups according to their protease content. We have compared the action of diverse secretagogues on bone marrow derived (BMMC) and peritoneal (PMC) mast cells which represent classical models of mucosal and connective tissue type mast cells in mice. Whereas, antigen stimulation of the FcεRI receptors was similarly effective in triggering elevations of free intracellular Ca

Indexed as

AnimalsBone Marrow CellsCalcium SignalingCell DegranulationMaleMast CellsMiceMice, Inbred C57BLMice, KnockoutPeritoneumReceptors, G-Protein-CoupledTRPC Cation ChannelsMrgprb2 protein, mouseReceptors, G-Protein-CoupledTRPC Cation Channelsconnective tissue type mast cellsintracellular calciummast cells degranulationMrgprb2 receptormucosal tissue type mast cellssecretagoguesTRPC channels

Identifiers

PMID32322252
PMCPMC7156601
OpenAlexW3015471235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.