Evidence map›Paper›PMID 32322200›Full record

ArticleFrontiers in pharmacology2020

Immunosuppressive Activity of

Amy M Zimmermann-Klemd, Jakob K Reinhardt, Anna Morath, Wolfgang W Schamel, Peter Steinberger, Judith Leitner, Roman Huber, Matthias Hamburger, Carsten Gründemann

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  4. Unveiling the multifaceted potential ofJournal of pharmaceutical analysis · 2026
    Review
  5. Immunomodulatory Effect ofAnimals : an open access journal from MDPI · 2025
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  6. Review
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  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Ethyl Acetate Extract fromMolecules (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Anti-Inflammatory Effect ofPlants (Basel, Switzerland) · 2021
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Amy M Zimmermann-KlemdCenter for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jakob K ReinhardtPharmaceutical Biology, Pharmacenter, University of Basel, Basel, Switzerland.
Anna MorathSignalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
Wolfgang W SchamelSignalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
Peter SteinbergerCenter for Pathophysiology, Infectiology, and Immunology, Institute of Immunology, Medical University of Vienna, Vienna, Austria.
Judith LeitnerCenter for Pathophysiology, Infectiology, and Immunology, Institute of Immunology, Medical University of Vienna, Vienna, Austria.
Roman HuberCenter for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Matthias HamburgerPharmaceutical Biology, Pharmacenter, University of Basel, Basel, Switzerland.
Carsten GründemannTranslational Complementary Medicine, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
University of Freiburg · DEUniversity of Basel · CHMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The need for novel drugs for the treatment of autoimmune diseases is high, since available pharmaceuticals often have substantial side effects and limited efficacy. Natural products are a good starting point in the development of immunosuppressive leads. Since enhanced T cell proliferation is a common feature of autoimmune diseases, we investigated the T cell proliferation inhibitory potential of an extract library of plants used in traditional Chinese medicine. Using a newly established cell-based screening platform, an ethyl acetate extract of

Indexed as

Artemisiaimmunosuppressioninterleukin-2sesquiterpene lactonesT cell signalling

Identifiers

PMID32322200
PMCPMC7157444
OpenAlexW3015414144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.