Evidence map›Paper›PMID 32322115›Full record

ArticleMacromolecules2018

Fabrication and Characterization of Hybrid Stealth Liposomes.

Kenneth P Mineart, Shrinivas Venkataraman, Yi Yan Yang, James L Hedrick, Vivek M Prabhu

Abstract read
In one paragraph

Article in Macromolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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  8. Cholesterol functionalized aliphaticPolymer chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kenneth P MineartMaterials Science and Engineering Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States.ORCID 0000-0003-2374-4670
Shrinivas VenkataramanInstitute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.ORCID 0000-0001-7037-1550
Yi Yan YangInstitute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.ORCID 0000-0002-1871-5448
James L HedrickIBM Almaden Research Center, 650 Harry Road, San Jose, California 95120, United States.ORCID 0000-0002-3621-9747
Vivek M PrabhuMaterials Science and Engineering Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States.ORCID 0000-0001-8790-9521

Funding

Intramural NIST DOC 9999-NIST
6 · The paper itself

Abstract

Next-generation liposome systems for anticancer and therapeutic delivery require the precise insertion of stabilizing polymers and targeting ligands. Many of these functional macromolecules may be lost to micellization as a competing self-assembly landscape. Here, hybrid stealth liposomes, which utilize novel cholesteryl-functionalized block copolymers as the molecular stabilizer, are explored as a scalable platform to address this limitation. The employed block copolymers offer resistance to micellization through multiple liposome insertion moieties per molecule. A combination of thermodynamic and structural investigations for a series of hybrid stealth liposome systems suggests that a critical number of cholesteryl moieties per molecule defines whether the copolymer will or will not insert into the liposome bilayer. Colloidal stability of formed hybrid stealth liposomes further corroborates the critical copolymer architecture value.

Identifiers

PMID32322115
PMCPMC7175670

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.