ArticleNature2020
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.
Abstract read
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Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.
0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed
21.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
175 citing papers in PubMed, 296 citations in OpenAlex.
- Stemness in Colon Cancer.Methods in molecular biology (Clifton, N.J.) · 2027Article
- An integrated spatially defined roadmap of normal and cancer-associated colon fibroblasts.Molecular systems biology · 2026Article
- Cellular crosstalk of fibroblast-myofibroblast transition in intestinal homeostasis and disease.Biomarker research · 2026Review
- Helicobacter pylori triggers gastric mucosal remodeling toward a fetal-like transcriptional program via stromal IL-1β signaling.Nature communications · 2026Article
- Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.Materials today. Bio · 2026Review
- Melatonin-inspired hybrid spheroids accelerate intestinal repair via YAP-driven fetal reprogramming.Asian journal of pharmaceutical sciences · 2026Article
- Current Status of Intestinal Stem Cell Research: Mechanisms, Intestinal Diseases, and Organoid Development.Cells · 2026Review
- Article
- Dynamic Reprogramming of PDGFRA-Expressing Stromal Cells Facilitates WNT-Driven Transformation by Promoting a Fetal-Like State in the Intestinal Epithelium.Cancer research · 2026Article
- Article
- Decoding the CAF-TAM axis: multi-omics dissection and therapeutic targeting of stromal-immune crosstalk in the tumor microenvironment.Cell death & disease · 2026Review
- Castl: robust identification of spatially variable genes in spatial transcriptomics via an ensemble-based framework.Briefings in bioinformatics · 2026Article
- Association Between Organophosphate Flame Retardant Exposure and Trouble Sleeping: Integrating Epidemiological Evidence with Mechanistic Insights.International journal of molecular sciences · 2026Article
- Review
- The immune microenvironment of colorectal cancer.Nature reviews. Cancer · 2025Review
- Role of metabolic reprogramming of cancer‑associated fibroblasts in tumor development and progression (Review).International journal of oncology · 2025Review
- Defining the mucosal ecosystem: epithelial-mesenchymal interdependence in gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025Review
- Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells.Nature biotechnology · 2025Article
- Organ-Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming.Aging cell · 2025Review
- Crosstalk between the circadian clock, intestinal stem cell niche, and epithelial cell fate decision.Genes & diseases · 2025Review
115 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 7 institutions in 3 countries.
Manolis Roulis *Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. emmanouil.roulis@yale.edu.ORCID http://orcid.org/0000-0002-6898-3547
Aimilios Kaklamanos *Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece.
Marina SchernthannerDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Piotr BieleckiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Jun ZhaoDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Eleanna KaffeDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Laura-Sophie FrommeltDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Rihao QuDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Marlene S KnappDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Ana HenriquesBiomedical Sciences Research Center 'Alexander Fleming', Vari, Greece.
Niki ChalkidiBiomedical Sciences Research Center 'Alexander Fleming', Vari, Greece.
Vasiliki KoliarakiBiomedical Sciences Research Center 'Alexander Fleming', Vari, Greece.
Jing JiaoDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
J Richard BrewerDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Maren BacherDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Holly N BlackburnDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Xiaoyun ZhaoShanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Richard M BreyerDepartment of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5828-4403
Vassilis AidinisBiomedical Sciences Research Center 'Alexander Fleming', Vari, Greece.
Dhanpat JainDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Bing SuShanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Harvey R HerschmanDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Yuval KlugerProgram of Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3035-071X
George KolliasBiomedical Sciences Research Center 'Alexander Fleming', Vari, Greece. kollias@fleming.gr.
Richard A FlavellDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. richard.flavell@yale.edu.ORCID http://orcid.org/0000-0003-4461-0778
Yale University · USAlexander Fleming Biomedical Sciences Research Center · GRShanghai Jiao Tong University · CNUniversity of California, Los Angeles · USHoward Hughes Medical Institute · USNational and Kapodistrian University of Athens · GRTennessee Valley Authority · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MEFFICIENT METHODS FOR CALIBRATION, CLUSTERING, VISUALIZATION AND IMPUTATION OF LARGE scRNA-seq DATAR01GM131642 · NIGMS · YALE UNIVERSITY · PI KLUGER, YUVAL · 2019 to 2022
$1.6MEFFICIENT SPECTRAL APPROACHES FOR FINDING UNDERLYING STRUCTURES IN BIG DATAR01HG008383 · NHGRI · YALE UNIVERSITY · PI KLUGER, YUVAL · 2016 to 2018
$1.2MHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NHGRI NIH HHS R01 HG008383NIGMS NIH HHS R01 GM131642
Abstract
The initiation of an intestinal tumour is a probabilistic process that depends on the competition between mutant and normal epithelial stem cells in crypts
Indexed as
CarcinogenesisParacrine CommunicationStem Cell NicheAdaptor Proteins, Signal TransducingAnimalsAntigens, LyArachidonic AcidCell Cycle ProteinsCell ProliferationColorectal NeoplasmsCyclooxygenase 2DinoprostoneFemaleFibroblastsHumansIntestinal MucosaAdaptor Proteins, Signal TransducingAntigens, LyArachidonic AcidCell Cycle ProteinsCyclooxygenase 2DinoprostoneLy6a protein, mouseMembrane ProteinsPTGER4 protein, humanPtger4 protein, mouseReceptors, Prostaglandin E, EP4 SubtypeYap1 protein, mouseYAP-Signaling Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.