Evidence map›Paper›PMID 32322013›Full record

ArticleScientific reports2020

The Liver and Kidneys mediate clearance of cardiac troponin in the rat.

Aida Muslimovic, Vincent Fridén, Olav Tenstad, Karin Starnberg, Susanne Nyström, Emelie Wesén, Elin K Esbjörner, Kristoffer Granholm, Bertil Lindahl, Ola Hammarsten

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Aida Muslimovic *Institute of Biomedicine, Department of Laboratory Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden.
Vincent Fridén *Institute of Biomedicine, Department of Laboratory Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden.
Olav TenstadDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Karin StarnbergInstitute of Biomedicine, Department of Laboratory Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden.
Susanne NyströmInstitute of Biomedicine, Department of Laboratory Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden.
Emelie WesénDepartment of Biology and Biotechnology, Biology and Biological Engineering, Chemical Biology, Chalmers University of Technology, Gothenburg, Sweden.
Elin K EsbjörnerDepartment of Biology and Biotechnology, Biology and Biological Engineering, Chemical Biology, Chalmers University of Technology, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-1253-6342
Kristoffer GranholmInstitute of Biomedicine, Department of Laboratory Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden.
Bertil LindahlDepartment of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Ola HammarstenInstitute of Biomedicine, Department of Laboratory Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden. ola.hammarsten@clinchem.gu.se.
Sahlgrenska University Hospital · SEChalmers University of Technology · SEUniversity of Bergen · NOUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac-specific troponins (cTn), troponin T (cTnT) and troponin I (cTnI) are diagnostic biomarkers when myocardial infarction is suspected. Despite its clinical importance it is still not known how cTn is cleared once it is released from damaged cardiac cells. The aim of this study was to examine the clearance of cTn in the rat. A cTn preparation from pig heart was labeled with fluorescent dye or fluorine 18 (

Indexed as

AnimalsFluorescent DyesFluorine RadioisotopesKidneyLiverMaleMetabolic Clearance RateMyocardiumPositron-Emission TomographyRats, Inbred WKYSwineTroponin TFluorescent DyesFluorine RadioisotopesTroponin T

Identifiers

PMID32322013
PMCPMC7176693
OpenAlexW3020164911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.