Evidence map›Paper›PMID 32321893›Full record

ArticleInternal medicine (Tokyo, Japan)2020

Effective Treatment with Tocilizumab in a Rheumatoid Arthritis Patient Complicated with Human T-cell Leukemia Virus Type 1-associated Myelopathy.

Chihiro Iwao, Kunihiko Umekita, Shunichi Miyauchi, Masatoshi Kimura, Yuki Rikitake, Koushou Iwao, Mao Rikitake, Ayako Aizawa, Takeshi Kawaguchi, Yumi Kariya and 4 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Chihiro IwaoDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Kunihiko UmekitaDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Shunichi MiyauchiDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Masatoshi KimuraDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Yuki RikitakeDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Koushou IwaoDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Mao RikitakeDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Ayako AizawaDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Takeshi KawaguchiDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Yumi KariyaDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Motohiro MatsudaDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Ichiro TakajoDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
Kazutaka ShiomiDivision of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Japan.
Akihiko OkayamaDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.
University of Miyazaki · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 61-year-old woman with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and interstitial pneumonia (IP) was admitted to our hospital. She complained of sicca symptoms, polyarthralgia, and swollen joints. She was diagnosed with rheumatoid arthritis (RA) and Sjögren's syndrome. Methotrexate and anti-tumor necrosis factor therapy were not utilized because of the inclusion of severe respiratory disorders among the complications and the neurological symptoms of HAM/TSP. Tocilizumab monotherapy improved the RA disease activity without exacerbating HAM/TSP. The present case suggests that tocilizumab might be a suitable treatment option in patients with RA and HAM/TSP.

Indexed as

Antibodies, Monoclonal, HumanizedArthritis, RheumatoidFemaleHumansHuman T-lymphotropic virus 1Middle AgedParaparesis, Tropical SpasticSjogren's SyndromeAntibodies, Monoclonal, Humanizedtocilizumabantirheumatic therapybiologichuman T-cell leukemia virus type 1myelopathyrheumatoid arthritistocilizumab

Identifiers

PMID32321893
PMCPMC7474999
OpenAlexW3020552208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.