Evidence map›Paper›PMID 32321818›Full record

ArticleJournal of virology2020

5-Methylcytosine RNA Modifications Promote Retrovirus Replication in an ALYREF Reader Protein-Dependent Manner.

Matthew Eckwahl, Ruyi Xu, Julia Michalkiewicz, Wen Zhang, Pooja Patel, Zhen Cai, Tao Pan

Abstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026
    Review
  4. Article
  5. Article
  6. Detection, molecular function and mechanisms of m5C in cancer.Clinical and translational medicine · 2025
    Review
  7. Article
  8. Review
  9. The role of m5C, m1A and m7G modifications in tumors of urinary system.Frontiers in cell and developmental biology · 2025
    Review
  10. Review
  11. Review
  12. Narrative review of research progress of RNA mTranslational cancer research · 2024
    Review
  13. Epitranscriptomic mScience advances · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Epigenetic addition of mCell death & disease · 2024
    Article
  19. mFrontiers in cell and developmental biology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew Eckwahl *Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.
Ruyi Xu *Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Julia MichalkiewiczDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.
Wen ZhangDepartment of Chemistry, University of Chicago, Chicago, Illinois, USA.
Pooja PatelDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.
Zhen CaiBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Tao PanDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA taopan@uchicago.edu.

Funding

Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
MULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5M
Recognition and mechanism of N6-methyl adenosine modificationsR01GM113194 · NIGMS · UNIVERSITY OF CHICAGO · PI PAN, TAO · 2015 to 2022
$2.5M
Defining the role of pseudouridine modifications in HIV biologyR56AI141343 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PAN, TAO, SIMON, VIVIANA A · 2019 to 2019
$679k
Global profiling of N6-methyladenosine (m6A) with Deam-seq and Circtron-seqF32GM126745 · NIGMS · UNIVERSITY OF CHICAGO · PI ECKWAHL, MATTHEW · 2018 to 2018
$34k
NHGRI NIH HHS RM1 HG008935NHLBI NIH HHS T32 HL007381NIAID NIH HHS R56 AI141343NIGMS NIH HHS F32 GM126745NIGMS NIH HHS R01 GM113194
6 · The paper itself

Abstract

RNA modifications play diverse roles in regulating RNA function, and viruses co-opt these pathways for their own benefit. While recent studies have highlighted the importance of

Indexed as

5-MethylcytosineAnimalsDNA MethylationGenome, ViralHEK293 CellsHumansLeukemia Virus, MurineMethyltransferasesMiceNIH 3T3 CellsNuclear ProteinsRetroviridaeRNA-Binding ProteinsRNA, MessengerRNA StabilityRNA, Viral5-MethylcytosineALYREF protein, humanMethyltransferasesNuclear ProteinsRNA-Binding ProteinsRNA, MessengerRNA, ViralTranscription Factors5-methylcytosineALYREFepitranscriptomemurine leukemia virusNSUN2retrovirusRNA modification

Identifiers

PMID32321818
PMCPMC7307164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.