Evidence map›Paper›PMID 32321757›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

IKZF3/Aiolos Is Associated with but Not Sufficient for the Expression of IL-10 by CD4

Michael L Ridley, Veerle Fleskens, Ceri A Roberts, Sylvine Lalnunhlimi, Aldana Alnesf, Aoife M O'Byrne, Kathryn J A Steel, Giovanni A M Povoleri, Jonathan Sumner, Paul Lavender and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. AIOLOS-Associated Inborn Errors of Immunity.Journal of clinical immunology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Michael L RidleyCentre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0002-3953-2384
Veerle FleskensCentre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, United Kingdom.
Ceri A RobertsCentre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0002-7900-667X
Sylvine LalnunhlimiCentre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, United Kingdom.
Aldana AlnesfCentre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, United Kingdom.
Aoife M O'ByrneCentre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0001-8185-2501
Kathryn J A SteelCentre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, United Kingdom.
Giovanni A M PovoleriCentre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0003-0342-651X
Jonathan SumnerDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom; and.
Paul LavenderMRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom.ORCID 0000-0001-8710-0263
Leonie S TaamsCentre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, United Kingdom; leonie.taams@kcl.ac.uk.ORCID 0000-0002-9337-7194
King's College London · GBGuy's Hospital · GB

Funding

Department of HealthVersus Arthritis 21139
6 · The paper itself

Abstract

The expression of anti-inflammatory IL-10 by CD4

Indexed as

CD3 ComplexCD4-Positive T-LymphocytesCoculture TechniquesGene Expression RegulationHEK293 CellsHumansIkaros Transcription FactorInterleukin-10LenalidomideLymphocyte ActivationRNA, MessengerTumor Necrosis Factor-alphaCD3 ComplexIkaros Transcription FactorIKZF3 protein, humanInterleukin-10LenalidomideRNA, MessengerTumor Necrosis Factor-alpha

Identifiers

PMID32321757
PMCPMC7231851
OpenAlexW3020218493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.