ArticlePsychological medicine2021
Sleep disturbance mediates the link between childhood trauma and clinical outcome in severe mental disorders.
Article in Psychological medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The Impact of Childhood Maltreatment on the Bipolar Disorder Course and Prognosis: A Systematic Review and Meta-Analysis.Clinical psychology & psychotherapyPooled it
- Differential associations of childhood trauma subtypes with clinical symptoms, cognitive function, suicidal intent, and age at onset in Chinese patients with chronic schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Interrelationships of childhood trauma, psychiatric symptoms, neurocognition, and insomnia in chronic schizophrenia: a network perspective.European archives of psychiatry and clinical neuroscience · 2026Article
- Psychological and behavioral mechanisms linking childhood trauma profiles to voice-related distress in schizophrenia spectrum disorders: latent class, mediation, and conditional process analyses.Psychological medicine · 2026Article
- The Association Between Childhood Trauma and Selective Serotonin Reuptake Inhibitor Treatment Outcomes in Adult Patients With Major Depressive Disorder.Psychiatry investigation · 2025Article
- Sleep duration in adolescence buffers the impact of childhood trauma on anxiety and depressive symptoms.BMC public health · 2025Article
- The day-to-day influence of trauma exposure and sleep dysfunction on everyday stress in youth at familial high-risk for psychotic disorders.Schizophrenia research · 2024Article
- A systematic review and meta-analysis of the traumatogenic phenotype hypothesis of psychosis.BJPsych open · 2024Review
- Association between childhood maltreatment and suicidal ideation among Chinese patients with chronic schizophrenia: the mediating role of insomnia.BJPsych open · 2024Article
- Impaired Sleep Mediates the Relationship Between Interpersonal Trauma and Subtypes of Delusional Ideation.Schizophrenia bulletin · 2024Article
- Prevalence and correlates of post-traumatic stress disorder and depression among welfare- and justice-involved adolescents in Nigeria.European journal of psychotraumatology · 2024Article
- Reported history of childhood trauma, mentalizing deficits, and hypersomnia in adulthood: A mediational analysis in a nonclinical sample.Brain and behavior · 2024Article
- Psychosocial factors of insomnia in depression: a network approach.BMC psychiatry · 2023Article
- Sleep disturbance as transdiagnostic mediator between adverse childhood experiences and psychopathology in children and adolescents: A structural equation modeling meta-analysis.JCPP advances · 2023Article
- The bridge symptoms of childhood trauma, sleep disorder and depressive symptoms: a network analysis.Child and adolescent psychiatry and mental health · 2023Article
- Childhood trauma and suicide risk in hospitalized patients with schizophrenia: the sequential mediating roles of pandemic related post-traumatic stress symptoms, sleep quality, and psychological distress.Frontiers in psychiatry · 2023Article
- Sleep disorders mediate the link between childhood trauma and depression severity in children and adolescents with depression.Frontiers in psychiatry · 2022Article
- Impact of adverse childhood experiences on the symptom severity of different mental disorders: a cross-diagnostic study.General psychiatry · 2022Article
- Childhood Trauma and Mental Health Status in General Population: A Series Mediation Examination of Psychological Distress in COVID-19 Pandemic and Global Sleep Quality.Frontiers in psychiatry · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe experience of childhood trauma is linked to more severe symptoms and poorer functioning in severe mental disorders; however, the mechanisms behind this are poorly understood. We investigate the relationship between childhood trauma and sleep disturbances in severe mental disorders including the role of sleep disturbances in mediating the relationship between childhood trauma and the severity of clinical symptoms and poorer functioning.
methodsIn total, 766 participants with schizophrenia-spectrum (n = 418) or bipolar disorders (n = 348) were assessed with the Childhood Trauma Questionnaire. Sleep disturbances were assessed through the sleep items in the self-reported Inventory of Depressive Symptoms. Clinical symptoms and functioning were assessed with The Positive and Negative Syndrome Scale and the Global Assessment of Functioning Scale. Mediation analyses using ordinary least squares regression were conducted to test if sleep disturbances mediated the relationship between childhood trauma and the severity of clinical symptoms and poorer functioning.
resultsSymptoms of insomnia, but not hypersomnia or delayed sleep phase, were significantly more frequent in participants with childhood trauma experiences compared to those without. Physical abuse, emotional abuse, and emotional neglect were significantly associated with insomnia symptoms. Insomnia symptoms partly mediate the relationship between childhood trauma and the severity of positive and depressive/anxiety symptoms, in addition to poorer functioning.
conclusionWe found frequent co-occurrence of childhood trauma history and current insomnia in severe mental disorders. Insomnia partly mediated the relationship between childhood trauma and the severity of clinical symptoms and functional impairment.
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