Evidence map›Paper›PMID 32321594›Full record

ArticleStem cell research & therapy2020

Enhanced therapeutic effects of MSC-derived extracellular vesicles with an injectable collagen matrix for experimental acute kidney injury treatment.

Yue Liu, Jian Cui, Hongfen Wang, Kamal Hezam, Xiaotong Zhao, Haoyan Huang, Shang Chen, Zhibo Han, Zhong-Chao Han, Zhikun Guo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

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  20. Extracellular Vesicle MicroRNA in the Kidney.Comprehensive Physiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yue LiuSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Jian CuiDepartment of Intensive Care Unit (ICU), People's Hospital of Rizhao, Rizhao, 276826, Shandong, China.
Hongfen WangState Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, 102218, China.
Kamal HezamSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Xiaotong ZhaoHenan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, Henan, China.
Haoyan HuangSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Shang ChenSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Zhibo HanJiangxi Engineering Research Center for Stem Cell, Shangrao, 334001, Jiangxi, China.
Zhong-Chao HanJiangxi Engineering Research Center for Stem Cell, Shangrao, 334001, Jiangxi, China.
Zhikun GuoHenan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, Henan, China. gzk@xxmu.edu.cn.
Zongjin LiSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, China. zongjinli@nankai.edu.cn.
Nankai University · CNChinese PLA General Hospital · CNXinxiang Medical University · CNPeople’s Hospital of Rizhao · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been shown to have therapeutic potential for ischemic diseases and are considered an alternative to cell therapy. However, the low retention and poor stability of EVs post-transplantation in vivo remain obstacle prior to the clinical application of EVs.

methodsThis study was designed to investigate whether collagen matrix could increase the retention and stability of EVs and further improve the therapeutic effects in murine acute kidney injury (AKI) model. EVs were isolated from human placental MSCs (hP-MSC-EVs) and encapsulated in a collagen matrix. Then, we investigated whether collagen matrix can prolong the retention of EVs in vivo, further enhancing the therapeutic efficiency of EVs in AKI.

resultsOur results indicated that collagen matrix could effectively encapsulate EVs, significantly increase the stability of EVs, and promote the sustained release of EVs. Collagen matrix has improved the retention of EVs in the AKI model, which was proved by Gaussia luciferase (Gluc) imaging. The application of collagen matrix remarkably facilitated the proliferation of renal tubular epithelial cells in AKI compared with EVs alone. Moreover, collagen matrix could further augment the therapeutic effects of hP-MSC-EVs as revealed by angiogenesis, fibrosis and apoptosis, and functional analysis. Finally, we found that EVs play a therapeutic role by inhibiting endoplasmic reticulum (ER) stress.

conclusionsCollagen matrix markedly enhanced the retention of EVs and further augmented the therapeutic effects of EVs for AKI. This strategy for improving the efficacy of EVs therapy provides a new direction for cell-free therapy.

Indexed as

Acute Kidney InjuryExtracellular VesiclesMesenchymal Stem CellsAnimalsCollagenFemaleHumansMicePlacentaPregnancyCollagenAcute kidney injury (AKI)Collagen matrixExtracellular vehicles (EVs)Mesenchymal stem cell (MSC)Molecular imaging

Identifiers

PMID32321594
PMCPMC7178991
OpenAlexW3018166893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.