ArticleStem cell research & therapy2020
Runx1t1 promotes the neuronal differentiation in rat hippocampus.
Article in Stem cell research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Role of caveolin-1 in metabolic programming of fetal brain.iScience · 2023Article
- Article
- Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming.Frontiers in cell and developmental biology · 2022Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
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Abstract
backgroundRunt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of radial glia cells in vitro.
methodsTo better uncover the role of Runx1t1 in hippocampal neurogenesis, in this study, we further explore its localization and function during the hippocampal neurogenesis.
resultsOur results showed that insufficient expression of Runx1t1 reduced the neuronal differentiation, and overexpression of Runx1t1 promoted the neuronal differentiation in vitro. We also found that Runx1t1 localized in neurons but not astrocytes both in vivo and in vitro. Furthermore, we found that Runx1t1 overexpression elevated the number of newborn neurons in the hippocampal dentate gyrus.
conclusionsTaken together, our results further proved that Runx1t1 could be worked as a regulator in the process of hippocampal neurogenesis.
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