ArticleParasites & vectors2020
Anopheles gambiae densovirus (AgDNV) negatively affects Mayaro virus infection in Anopheles gambiae cells and mosquitoes.
Article in Parasites & vectors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Effects of insect-specific viruses on transmission, infection, and replication of arboviruses in co-infected mosquitoes: a systematic review.Parasites & vectors · 2026Pooled it
- Infectious transgenesis in arthropods.bioRxiv : the preprint server for biology · 2026Article
- Evaluating the Role ofViruses · 2026Review
- Physiological Impacts on the Mosquito Vector Hosts Refine Vectorial Capacity Estimates of Mayaro Virus Transmission Risk.Viruses · 2025Article
- Effect of prolonged dehydration stress on the vector competence ofbioRxiv : the preprint server for biology · 2025Article
- Eilat virus (EILV) causes superinfection exclusion against West Nile virus (WNV) in a strain-specific manner inThe Journal of general virology · 2024Article
- Exploring mosquito virome dynamics within São Paulo Zoo: insights into mosquito-virus-environment interactions.Frontiers in cellular and infection microbiology · 2024Article
- Dehydration stress and Mayaro virus vector competence inJournal of virology · 2023Article
- Article
- Mosquito densovirus significantly reduces the vector susceptibility to dengue virus serotype 2 in Aedes albopictus mosquitoes (Diptera: Culicidae).Infectious diseases of poverty · 2023Article
- Article
- Sexual transmission of Anopheles gambiae densovirus (AgDNV) leads to disseminated infection in mated females.Parasites & vectors · 2022Article
- Symbiotic Interactions Between Mosquitoes and Mosquito Viruses.Frontiers in cellular and infection microbiology · 2021Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent studies demonstrate that insect-specific viruses can influence the ability of their mosquito hosts to become infected with and transmit arboviruses of medical and veterinary importance. The aim of this study was to evaluate the interactions between Anopheles gambiae densovirus (AgDNV) (Parvoviridae) (a benign insect-specific virus that infects An. gambiae mosquitoes) and Mayaro virus (MAYV) (Togaviridae) (an emerging human pathogen that can be transmitted by An. gambiae) in both insect cell culture and mosquitoes.
methodsFor in vitro studies, An. gambiae Mos55 cells infected or uninfected with AgDNV were infected with MAYV. For in vivo studies, An. gambiae mosquitoes were injected intrathoracically with AgDNV and 4 days later orally infected with MAYV. Mosquitoes were dissected 10 days after MAYV infection, and MAYV titers in the body, legs and saliva samples quantified using focus-forming assay.
resultsMAYV virus replication was reduced 10-100-fold in An. gambiae Mos55 cells infected with AgDNV. In mosquitoes, there was a significant negative correlation between AgDNV and MAYV body titers 10 days post-blood meal.
conclusionsAgDNV infection was associated with reduced production of MAYV in cell culture, and reduced body titers of MAYV in An. gambiae mosquitoes. As densovirus infections are common in natural mosquito populations, these data suggest that they may affect the epidemiology of viruses of medical importance.
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