Evidence map›Paper›PMID 32321553›Full record

ArticleRadiation oncology (London, England)2020

Development and external validation of a nomogram to predict overall survival following stereotactic body radiotherapy for early-stage lung cancer.

Sarah Baker, Katerina Bakunina, Marloes Duijm, Mischa S Hoogeman, Robin Cornelissen, Imogeen Antonisse, John Praag, Wilma D Heemsbergen, Joost Jan Nuyttens

Open access · goldAbstract read
In one paragraph

Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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  6. CT-based radiomics prediction of complete response after stereotactic body radiation therapy for patients with lung metastases.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sarah BakerDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 302, Postbus 2040, 3000 CA, Rotterdam, The Netherlands. baker2@ualberta.ca.
Katerina BakuninaDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 302, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
Marloes DuijmDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 302, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
Mischa S HoogemanDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 302, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
Robin CornelissenDepartment of Pulmonary Medicine, Erasmus MC Cancer Institute, s Gravendijkwal 230, 3015 CD, Rotterdam, The Netherlands.
Imogeen AntonisseDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 302, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
John PraagDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 302, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
Wilma D HeemsbergenDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 302, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
Joost Jan NuyttensDepartment of Radiation Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 302, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
Erasmus MC Cancer Institute · NL

Funding

Accuray Incorporated N/A
6 · The paper itself

Abstract

backgroundPrognostication tools for early-stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) are currently lacking. The purpose of this study was to develop and externally validate a nomogram to predict overall survival in individual patients with peripheral early-stage disease.

methodsA total of 587 NSCLC patients treated with biologically effective dose > 100 Gy

resultsThe resulting nomogram was based on six prognostic factors: age, sex, Karnofsky Performance Status, operability, Charlson Comorbidity Index, and tumor diameter. The slope of the calibration curve for nomogram-predicted versus Kaplan-Meier-estimated overall survival was 0.77. The C-index of the nomogram (corrected for optimism) was moderate at 0.64. In the external validation cohort, the model yielded a C-index of 0.62.

conclusionsWe established and validated a nomogram which can provide individual survival predictions for patients with early stage lung cancer treated with SBRT. The nomogram may assist patients and clinicians with treatment decision-making.

Indexed as

NomogramsAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungFemaleHumansLung NeoplasmsMaleMiddle AgedPrognosisProportional Hazards ModelsRadiosurgeryReproducibility of ResultsIndividual survival predictionLung neoplasmNon-small cellRadiation

Identifiers

PMID32321553
PMCPMC7178957
OpenAlexW3017747879

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.