Evidence map›Paper›PMID 32321445›Full record

ArticleBMC developmental biology2020

The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits.

Gongyan Liu, Shu Li, Hongli Liu, Yanli Zhu, Liya Bai, Haitao Sun, Shuxia Gao, Wenxue Jiang, Fuchang Li

Open access · hybridAbstract read
In one paragraph

Article in BMC developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gongyan LiuCollege of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, People's Republic of China.
Shu LiCollege of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, People's Republic of China.
Hongli LiuCollege of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, People's Republic of China.
Yanli ZhuCollege of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, People's Republic of China.
Liya BaiAnimal Husbandry and Veterinary Institute, Shandong Academy of Agricultural Sciences, Jinan, 251000, People's Republic of China.
Haitao SunAnimal Husbandry and Veterinary Institute, Shandong Academy of Agricultural Sciences, Jinan, 251000, People's Republic of China.
Shuxia GaoAnimal Husbandry and Veterinary Institute, Shandong Academy of Agricultural Sciences, Jinan, 251000, People's Republic of China.
Wenxue JiangAnimal Husbandry and Veterinary Institute, Shandong Academy of Agricultural Sciences, Jinan, 251000, People's Republic of China.
Fuchang LiCollege of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, People's Republic of China. chlf@sdau.edu.cn.ORCID 0000-0002-5670-8038
China Animal Disease Control Center · CNShandong Agricultural University · CN

Funding

Earmarked Fund for Modern Agro-industry Technology Research System CARS-43-B-1Funds of Shandong "Double Tops" Programme SYL2017YSTD11National Natural Science Foundation of China 31972594
6 · The paper itself

Abstract

backgroundHair follicles are an appendage of the vertebrate epithelium in the skin that arise from the embryonic ectoderm and regenerate cyclically during adulthood. Dermal papilla cells (DPCs) are the key dermal component of the hair follicle that directly regulate hair follicle development, growth and regeneration. According to recent studies, miRNAs play an important role in regulating hair follicle morphogenesis and the proliferation, differentiation and apoptosis of hair follicle stem cells.

resultsThe miRNA expression profile of the DPCs from Rex rabbits with different hair densities revealed 240 differentially expressed miRNAs (|log

conclusionsIn the present study, ocu-miR-205 promoted the apoptosis of DPCs, altered the expression of genes and proteins involved in the PI3K/Akt, Wnt, Notch and BMP signalling pathways in DPCs and skin from Rex rabbits, promoted the transition of hair follicles from the growth phase to the regression and resting phase, and altered the hair density of Rex rabbits.

Indexed as

Animalsbeta CateninBone Morphogenetic Protein ReceptorsGene Products, rexGlycogen Synthase Kinase 3 betaHair FollicleMicroRNAsPhosphorylationRabbitsReceptors, Notchbeta CateninBone Morphogenetic Protein ReceptorsGene Products, rexGlycogen Synthase Kinase 3 betaMicroRNAsReceptors, NotchDermal papilla cellHair follicle densityOcu-miR-205Rex rabbit

Identifiers

PMID32321445
PMCPMC7178635
OpenAlexW3018003346

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.