Evidence map›Paper›PMID 32321443›Full record

ArticleBMC geriatrics2020

Age-dependent effect of metabolic phenotypes on carotid atherosclerotic disease in coronary heart disease patients (CORDIOPREV study).

Francisco M Gutierrez-Mariscal, Antonio García-Ríos, Purificación Gómez-Luna, Carolina Fernández-Gandara, Magdalena P Cardelo, Silvia de la Cruz-Ares, Fernando Rodriguez-Cantalejo, Raul M Luque, Ana León-Acuña, Javier Delgado-Lista and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Francisco M Gutierrez-MariscalLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.ORCID 0000-0003-3353-2188
Antonio García-RíosLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.
Purificación Gómez-LunaLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.
Carolina Fernández-GandaraLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.
Magdalena P CardeloLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.
Silvia de la Cruz-AresLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.ORCID 0000-0002-9013-228X
Fernando Rodriguez-CantalejoBiochemical Laboratory, Reina Sofia University Hospital, Córdoba, Spain.
Raul M LuqueCIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain.
Ana León-AcuñaLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.
Javier Delgado-ListaLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.
Pablo Perez-MartinezLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.
Elena M Yubero-SerranoLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain.ORCID 0000-0002-2733-5359
Jose Lopez-MirandaLipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), University of Córdoba, 14004, Córdoba, Spain. jlopezmir@uco.es.ORCID 0000-0002-8844-0718
Instituto de Salud Carlos III · ESHospital Universitario Reina Sofía · ES

Funding

Agencia de Innovación y Desarrollo de Andalucía CVI-7450Agencia Estatal de Investigación AGL2012-39615Agencia Estatal de Investigación AGL2015-67896-PConsejería de Salud, Junta de Andalucía PI-0058/10Consejería de Salud, Junta de Andalucía PI0193/09Consejería de Salud, Junta de Andalucía PI-0252/09
6 · The paper itself

Abstract

backgroundAging is associated with a high risk for cardiovascular disease. The relation of obesity and risk of cardiovascular events appears to be more closely linked to certain clinical or metabolic phenotypes than to obesity itself. Our aim was to establish whether aging influenced the metabolic phenotypes regarding to cardiovascular risk, evaluated by changes in the intima media thickness-common carotid (IMT-CC), in coronary heart disease (CHD) patients.

methodsIn this cross-sectional study, 1002 CHD patients were studied at entry from the CORDIOPREV study. We performed carotid ultrasound assessment to obtain their IMT-CC values. Carotid atherosclerosis was considered to exist if IMT-CC > 0.7 mm.

resultsAge determined a higher IMT-CC, regardless metabolic phenotype (all p < 0.05). Metabolically healthy non-obese (MHNO) aged< 60 showed a lesser prevalence for carotid atherosclerotic disease than metabolically sick non-obese (MSNO) and obese (MSO), while MHNO aged≥60 only showed less prevalence for the disease than the MSO. Carotid atherosclerosis associated with age, sex, impaired fasting glucose (IFG), hypertension and high sensitivity C-reactive protein (hsCRP). However, in patients aged< 60, it associated with sex and IFG and in the age ≥ 60 group, with hypertension and hsCRP.

conclusionsOur results suggest that CHD patients aged≥60 are less metabolic flexible compared to patients aged< 60. Thus, MHO patients aged≥60 show the same risk of suffering carotid atherosclerosis as those with metabolic disease, while MHO patients aged< 60 show lower risk than MSO. This fact indicates the need to focus on therapeutic strategies in order to modify those parameters related to obesity and metabolic inflexibility in patients with CHD before entering old age.

Indexed as

Carotid Intima-Media ThicknessAdultAgedAge FactorsCarotid ArteriesCarotid Artery DiseasesCoronary DiseaseCross-Sectional StudiesFemaleHumansMaleMiddle AgedObesity, AbdominalPhenotypePlaque, AtheroscleroticPrevalenceCardiovascular risk factorsCarotid atherosclerosisMetabolically healthy obeseMetabolic flexibility

Identifiers

PMID32321443
PMCPMC7178935
OpenAlexW3018199421

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.