Evidence map›Paper›PMID 32320899›Full record

ReviewCurrent opinion in immunology2020

Microbiota-immune interactions in asthma pathogenesis and phenotype.

Nicholas W Lukacs, Yvonne J Huang

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Microbiome modifications by steroids during viral exacerbation of asthma and in healthy mice.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Diet, Asthma, and Severe Asthma Exacerbations in a Prospective Study of Puerto Rican Youth.The journal of allergy and clinical immunology. In practice · 2022
    Article
  15. The Lung Microbiome during Health and Disease.International journal of molecular sciences · 2021
    Review
  16. Pulmonary Surfactants: a New Therapeutic Target in Asthma.Current allergy and asthma reports · 2020
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nicholas W LukacsDepartment of Pathology and Mary H. Weiser Food Allergy Center, United States.
Yvonne J HuangDivision of Pulmonary and Critical Medicine, Department of Medicine, University of Michigan, Ann Arbor, United States. Electronic address: yvjhuang@med.umich.edu.

Funding

Viral and allergen-driven immunity in chronic lung diseaseR35HL150682 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nicholas W Lukacs · 2020 to 2026
$4.8M
Sputum Microbial Markers of Type 2-Low AsthmaR01AI129958 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUANG, YVONNE JEAN · 2017 to 2021
$3.6M
Neonatal RSV infection and alteration of allergic immune responsesR01AI138348 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUFFNAGLE, GARY B, LUKACS, NICHOLAS W · 2018 to 2022
$2.2M
NHLBI NIH HHS R35 HL150682NIAID NIH HHS R01 AI129958NIAID NIH HHS R01 AI138348
6 · The paper itself

Abstract

The complexity and the mechanistic role of microbial communities at mucosal surfaces are only now beginning to be understood. Their impact on host metabolism, development, and immune responses to infectious and inert stimuli may be centrally linked to the metabolic functions of these communities within the established microbiome. The structure and function of microbial communities are influenced both early and throughout life by many environmental factors, exposures, diet, and disease. Understanding how the microbiome influences the host during health is likely just as important as understanding how it influences asthmatic disease predisposition and severity.

Indexed as

AsthmaHumansMicrobiotaPhenotype

Identifiers

PMID32320899
PMCPMC9092633

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.