Evidence map›Paper›PMID 32320734›Full record

ArticleThe Journal of allergy and clinical immunology2020

Human T

Lyndsey M Muehling, Peter W Heymann, Paul W Wright, Jacob D Eccles, Rachana Agrawal, Holliday T Carper, Deborah D Murphy, Lisa J Workman, Carolyn R Word, Sarah J Ratcliffe and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 52 citations in OpenAlex.

  1. The rhinovirus puzzle: Linking virus and host factors to childhood asthma.The Journal of allergy and clinical immunology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Frequent exacerbator-a novel endotype of pediatric asthma.The Journal of allergy and clinical immunology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. The role of innate immune system in respiratory viral infection related asthma.Frontiers in cellular and infection microbiology · 2025
    Review
  12. Review
  13. Novel Role of the GSDMB/IFNG Axis in Childhood Asthma.American journal of respiratory and critical care medicine · 2024
    Article
  14. Review
  15. CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma.The Journal of allergy and clinical immunology · 2023
    Article
  16. T helper 2 cells in asthma.The Journal of experimental medicine · 2023
    Review
  17. Employing T-Cell Memory to Effectively Target SARS-CoV-2.Pathogens (Basel, Switzerland) · 2023
    Review
  18. Review
  19. Development of Adaptive Immunity and Its Role in Lung Remodeling.Advances in experimental medicine and biology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Lyndsey M MuehlingDepartment of Medicine, University of Virginia School of Medicine, Charlottesville; Department of Microbiology, University of Virginia School of Medicine, Charlottesville.
Peter W HeymannDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville.
Paul W WrightDepartment of Medicine, University of Virginia School of Medicine, Charlottesville.
Jacob D EcclesDepartment of Medicine, University of Virginia School of Medicine, Charlottesville; Department of Microbiology, University of Virginia School of Medicine, Charlottesville.
Rachana AgrawalDepartment of Medicine, University of Virginia School of Medicine, Charlottesville.
Holliday T CarperDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville.
Deborah D MurphyDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville.
Lisa J WorkmanDepartment of Medicine, University of Virginia School of Medicine, Charlottesville.
Carolyn R WordDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville.
Sarah J RatcliffeDepartment of Public Health Sciences, University of Virginia School of Medicine, Charlottesville.
Brian J CapaldoDepartment of Microbiology, University of Virginia School of Medicine, Charlottesville.
Thomas A E Platts-MillsDepartment of Medicine, University of Virginia School of Medicine, Charlottesville.
Ronald B TurnerDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville.
William W KwokBenaroya Research Institute at Virginia Mason, Seattle.
Judith A WoodfolkDepartment of Medicine, University of Virginia School of Medicine, Charlottesville; Department of Microbiology, University of Virginia School of Medicine, Charlottesville. Electronic address: jaw4m@virginia.edu.
University of Virginia · USVirginia Mason Medical Center · US

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory diseaseR37AI020565 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI THOMAS A. PLATTS-MILLS · 1992 to 2026
$8.4M
DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMAR01AI020565 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PLATTS-MILLS, THOMAS A. · 1985 to 2017
$7.1M
An Evaluation of Treatment with Omalizumab to Improve the Asthmatic Response to aU01AI100799 · NIAID · UNIVERSITY OF VIRGINIA · PI HEYMANN, PETER W, PLATTS-MILLS, THOMAS A. · 2012 to 2015
$5.3M
Hallmarks of Protective Immunity in Sequential Rhinovirus Infections in HumansU01AI125056 · NIAID · UNIVERSITY OF VIRGINIA · PI WOODFOLK, JUDITH A · 2016 to 2020
$4.1M
Exploring Amplified Th1 Responses and a Role for the IgE/Interferon Axis in Allergic Asthmatics Infected with RhinovirusR21AI138077 · NIAID · UNIVERSITY OF VIRGINIA · PI WOODFOLK, JUDITH A · 2019 to 2020
$437k
NIAID NIH HHS R01 AI020565NIAID NIH HHS R21 AI138077NIAID NIH HHS R37 AI020565NIAID NIH HHS T32 AI007496NIAID NIH HHS U01 AI100799NIAID NIH HHS U01 AI125056
6 · The paper itself

Abstract

backgroundAllergic asthmatic subjects are uniquely susceptible to acute wheezing episodes provoked by rhinovirus. However, the underlying immune mechanisms and interaction between rhinovirus and allergy remain enigmatic, and current paradigms are controversial.

objectiveWe sought to perform a comprehensive analysis of type 1 and type 2 innate and adaptive responses in allergic asthmatic subjects infected with rhinovirus.

methodsCirculating virus-specific T

resultsIn uninfected asthmatic subjects, higher numbers of circulating virus-specific PD-1

conclusionsRhinovirus induces robust T

Indexed as

AllergensAntigens, ViralAsthmaCells, CulturedCytokinesDisease SusceptibilityHumansHypersensitivityLymphocyte ActivationPicornaviridae InfectionsProgrammed Cell Death 1 ReceptorRespiratory SoundsRhinovirusTh1 CellsTh2 CellsAllergensAntigens, ViralCytokinesPDCD1 protein, humanProgrammed Cell Death 1 Receptoranti-IgEasthmacytokinesIFNRhinovirusT cellstetramersT(H)1T(H)2

Identifiers

PMID32320734
PMCPMC7483727
OpenAlexW3016402276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.