Evidence map›Paper›PMID 32320701›Full record

ArticleEuropean journal of pharmacology2020

Mesenteric arterial dysfunction in the UC Davis Type 2 Diabetes Mellitus rat model is dependent on pre-diabetic versus diabetic status and is sexually dimorphic.

Sonali Shaligram, Farjana Akther, Md Rahatullah Razan, James L Graham, Núria Roglans, Marta Alegret, Arta Gharib Parsa, Kimber L Stanhope, Peter J Havel, Roshanak Rahimian

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sonali ShaligramDepartment of Physiology & Pharmacology, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA, 95211, USA.
Farjana AktherDepartment of Physiology & Pharmacology, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA, 95211, USA.
Md Rahatullah RazanDepartment of Physiology & Pharmacology, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA, 95211, USA.
James L GrahamDepartment of Molecular Biosciences, School of Veterinary Medicine, Department of Nutrition, University of California, Davis, CA, 95616, USA.
Núria RoglansDepartment of Pharmacology, Toxicology, and Therapeutic Chemistry, School of Pharmacy, University of Barcelona, Barcelona, Spain.
Marta AlegretDepartment of Pharmacology, Toxicology, and Therapeutic Chemistry, School of Pharmacy, University of Barcelona, Barcelona, Spain.
Arta Gharib ParsaDepartment of Physiology & Pharmacology, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA, 95211, USA.
Kimber L StanhopeDepartment of Molecular Biosciences, School of Veterinary Medicine, Department of Nutrition, University of California, Davis, CA, 95616, USA.
Peter J HavelDepartment of Molecular Biosciences, School of Veterinary Medicine, Department of Nutrition, University of California, Davis, CA, 95616, USA.
Roshanak RahimianDepartment of Physiology & Pharmacology, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA, 95211, USA. Electronic address: rrahimian@pacific.edu.
University of the Pacific · USUniversity of California, Davis · USUniversitat de Barcelona · ES

Funding

Mouse Metabolic Phenotyping Center (MMPC) at UC DavisU2CDK092993 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2016 to 2021
$5.9M
Adverse Metabolic Effects of Dietary Sugar _ Ad Libitum vs Energy-Balanced DietsR01HL121324 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J, SCHWARZ, JEAN-MARC · 2014 to 2019
$4.2M
Mouse Metabolic Phenotyping Center (MMPC) at UC DavisU24DK092993 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2011 to 2015
$4.1M
Dissecting mechanisms by which GI surgery delays diabetes onset in UCD-T2DM ratsR01DK095960 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CUMMINGS, BETHANY PAIGE, HAVEL, PETER J · 2012 to 2015
$1.3M
Diabetes, Estrogen and Endothelial DysfunctionR15HL128988 · NHLBI · UNIVERSITY OF THE PACIFIC-STOCKTON · PI RAHIMIAN, ROSHANAK · 2016 to 2016
$302k
NHLBI NIH HHS R01 HL121324NHLBI NIH HHS R15 HL128988NIDDK NIH HHS R01 DK095960NIDDK NIH HHS U24 DK092993NIDDK NIH HHS U2C DK092993
6 · The paper itself

Abstract

Previous reports suggest that diabetes may differentially affect the vascular beds of females and males. However, there is insufficient evidence to establish the timeline of the vascular dysfunction in diabetes, specifically in relation to sex. Here, we determined whether mesenteric arterial function is altered in UC Davis Type-2 Diabetes Mellitus (UCD-T2DM) rats and if this occurs as early as the pre-diabetic stage of the disease. Specifically, we investigated whether vascular dysfunction differs between pre-diabetic or diabetic status and if this varies by sex. We measured the responses to endothelium-dependent and -independent vasorelaxant as well as vasoconstrictor agents and explored the potential mechanisms involved in sex-specific development of arterial dysfunction in UCD-T2DM rats. In addition, indices of insulin sensitivity were assessed. We report the reduced insulin sensitivity in pre-diabetic males and diabetic females. Vascular relaxation to acetylcholine was impaired to a greater extent in mesenteric artery from males in the pre-diabetic stage than in their female counterparts. In contrast, the arteries from females with diabetes exhibited a greater impairment to acetylcholine compared with diabetic males. Additionally, the sensitivity of mesenteric artery to contractile agents in females, but not in males, after the onset of diabetes was increased. Our data suggest that the reduced insulin sensitivity through AKT may predispose vessels to injury in the pre-diabetic stage in males. On the other hand, reduced insulin sensitivity as well as enhanced responsiveness to contractile agents may predispose arteries to injury in the diabetic stage in females.

Indexed as

AnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FemaleInsulinInsulin ResistanceMaleMesenteric ArteriesPrediabetic StateRatsSex CharacteristicsInsulinEndothelial dysfunctionInsulin sensitivityMesenteric arteryPre-diabetesSex differencesType-2 diabetes

Identifiers

PMID32320701
PMCPMC7304887
OpenAlexW3016496733

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.