ArticleHormones and behavior2020
Maternal exposure to organophosphate flame retardants alters locomotor and anxiety-like behavior in male and female adult offspring.
Article in Hormones and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Firemaster 550 differentially alters gene expression underlying synaptic function in amygdala of prairie voles after gestational or lactational exposure.Neurotoxicology · 2026Article
- PERINATAL ORGANOPHOSPHATE FLAME RETARDANT EXPOSURE ALTERS ADULT HPA AXIS FUNCTION AND AVOIDANCE BEHAVIOR IN A SEX-SPECIFIC MANNER IN MICE.bioRxiv : the preprint server for biology · 2025Article
- Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort.Environment international · 2025Article
- Article
- Developmental immunotoxicity study of tris(chloropropyl) phosphate in Hsd:Sprague Dawley SD rats exposed through dosed feed.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Mechanisms of Flame Retardant Toxicity and Their Impacts on Anxiety and Cognition in the Brain.Endocrinology · 2025Review
- Impact of exposure to a mixture of organophosphate esters on the adrenal glands of Sprague Dawley rats.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- House dust-derived mixtures of organophosphate esters alter the phenotype, function, transcriptome, and lipidome of KGN human ovarian granulosa cells.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Article
- Rapid and Comprehensive Analysis of 41 Harmful Substances in Multi-Matrix Products by Gas Chromatography-Mass Spectrometry Using Matrix-Matching Calibration Strategy.Materials (Basel, Switzerland) · 2024Article
- Prenatal exposures to organophosphate ester metabolites and early motor development in the MADRES cohort.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Developmental stage-specific exposure and neurotoxicity evaluation of low-dose clothianidin during neuronal circuit formation.The Journal of veterinary medical science · 2023Article
- Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Developmental exposure to the flame retardant, triphenyl phosphate, causes long-lasting neurobehavioral and neurochemical dysfunction.Birth defects research · 2023Article
- Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity.Biomolecules · 2022Article
- A single-cell survey unveils cellular heterogeneity and sensitive responses in mouse cortices induced by oral exposure to triphenyl phosphate.Archives of toxicology · 2022Article
- The influence of estrogen receptor α signaling independent of the estrogen response element on avoidance behavior, social interactions, and palatable ingestive behavior in female mice.Hormones and behavior · 2021Article
- Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers.Environmental health perspectives · 2021Article
- Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture.Endocrinology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Endocrine disrupting chemicals (EDCs) are chemicals found in our environment that interrupt typical endocrine function. Some flame retardants (FRs) are EDCs as shown in their interaction with steroid and nuclear receptors. Humans are consistently exposed to flame retardants as they are used in everyday items such as plastics, clothing, toys, and electronics. Polybrominated diphenyl ethers were used as the major FR until 2004, when they were replaced by organophosphate flame retardants (OPFRs). Previous research in rodent models utilizing a commercial flame retardant mixture containing OPFRs reported alterations in anxiety-like behavior in the elevated plus maze (EPM) for rodents perinatally exposed to OPFRs. In the present study we utilize wild-type mice maternally exposed (gestational day 7 to postnatal day 14) to either an OPFR mixture of tris(1,3-dichloro-2-propyl), triphenyl phosphate, and tricresyl phosphate or a sesame seed oil vehicle. These mice were evaluated for anxiety-like behavior in adulthood on the open field test (OFT) and the light/dark box (LDB) as well as the EPM. Outcomes from the OFT and LDB indicate that males and females maternally exposed to OPFRs exhibit altered locomotor activity. Results of the EPM were sex-specific as we did not observe an effect in females; however, effects in males differed depending on exposure condition. Males maternally exposed to OPFRs exhibited an anxiolytic-like phenotype in contrast to their vehicle counterparts. This effect in perinatally OPFR-exposed males was not due to alterations in locomotor activity. Our research illustrates that there are sex- and exposure-dependent effects of perinatal OPFR exposure on adult locomotor and anxiety-like behaviors in a mouse model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.