ArticlePlant biotechnology journal2020
Development of zeaxanthin-rich tomato fruit through genetic manipulations of carotenoid biosynthesis.
Article in Plant biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Metabolism and regulation of chlorophyll and carotenoids in tomato fruits.Horticulture research · 2026Article
- Crop biofortification for global food security: advances in genetic engineering and biotechnological approaches.Plant molecular biology · 2026Review
- Green metabolic engineering of Synechocystis sp. PCC 6803 for efficient production and sustainable extraction of β-cryptoxanthin and zeaxanthin.Microbial cell factories · 2026Article
- Natural CCD2 Variants and RNA Interference for Boosting Crocin Biosynthesis in Tomato.Biology · 2025Article
- Article
- Optimizing a tomato crocin biofactory by fine-tuning plant architecture.Frontiers in plant science · 2025Article
- Article
- Comparative Analysis of Individual Carotenoid Profiles in Yellow- and White-Fleshed Potatoes (Foods (Basel, Switzerland) · 2024Article
- QTL Mapping of Zeaxanthin Content in Sweet Corn Using Recombinant Inbred Line Population across Different Environments.Plants (Basel, Switzerland) · 2023Article
- Article
- The role of forkhead-associated (FHA)-domain proteins in plant biology.Plant molecular biology · 2023Review
- CRISPR/Cas9-mediated SNAC9 mutants reveal the positive regulation of tomato ripening by SNAC9 and the mechanism of carotenoid metabolism regulation.Horticulture research · 2023Article
- Resequencing of sweetpotato germplasm resources reveals key loci associated with multiple agronomic traits.Horticulture research · 2023Article
- Enrichment of health-promoting lutein and zeaxanthin in tomato fruit through metabolic engineering.Synthetic and systems biotechnology · 2022Article
- A whiff of the future: functions of phenylalanine-derived aroma compounds and advances in their industrial production.Plant biotechnology journal · 2022Review
- Does Plant Breeding for Antioxidant-Rich Foods Have an Impact on Human Health?Antioxidants (Basel, Switzerland) · 2022Review
- The metabolic changes that effect fruit quality during tomato fruit ripening.Molecular horticulture · 2022Review
- Fruit ripening: dynamics and integrated analysis of carotenoids and anthocyanins.BMC plant biology · 2022Review
- Engineering high levels of saffron apocarotenoids in tomato.Horticulture research · 2022Article
- Glycine-rich RNA-binding cofactor RZ1AL is associated with tomato ripening and development.Horticulture research · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oxygenated carotenoid zeaxanthin provides numerous benefits to human health due to its antioxidant properties. Especially it is linked to protecting, together with the xanthophyll lutein, the retina in the human eye by filtering harmful blue light thus delaying the progression of age-related macular degeneration (AMD), the most prevalent cause of blindness in developed countries. Despite its high nutritional value, zeaxanthin is less available than other substantial carotenoids in our diet. To solve this shortage, we chose to develop a new food source that would contain a high concentration of natural zeaxanthin. Tomato (Solanum lycopersicum L.) was selected as the target plant since it is the second largest vegetable crop grown worldwide and its fruit characteristically synthesizes and accumulates a high concentration of carotenoids. We employed two genetic approaches in order to enhance zeaxanthin biosynthesis in tomato fruit: a transgenic metabolic engineering and classical genetic breeding. A nontransgenic tomato line, named 'Xantomato', was generated whose fruit accumulated zeaxanthin at a concentration of 39 μg/g fresh weight (or 577 μg/g dry weight), which comprised ca. 50% of total fruit carotenoids compared to zero in the wild type. This is the highest concentration of zeaxanthin reached in a primary crop. Xantomato can potentially increase zeaxanthin availability in the human diet and serve as raw material for industrial applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.