Evidence map›Paper›PMID 32320267›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Gene expression profiling of bronchial brushes is associated with the level of emphysema measured by computed tomography-based parametric response mapping.

Senani N H Rathnayake, Firdaus A A Mohamed Hoesein, Craig J Galban, Nick H T Ten Hacken, Brian G G Oliver, Maarten van den Berge, Alen Faiz

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Blood Biomarkers of Emphysema: What Can They Really Tell Us?American journal of respiratory and critical care medicine · 2024
    Article
  3. Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema.American journal of respiratory and critical care medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Senani N H RathnayakeRespiratory Bioinformatics and Molecular Biology, School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-5631-7264
Firdaus A A Mohamed HoeseinDivision of Heart and Lungs, Department of Respiratory Medicine, University Medical Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-2536-9384
Craig J GalbanDepartment of Radiology, The University of Michigan, Ann Arbor, Michigan.
Nick H T Ten HackenGroningen Research Institute for Asthma and COPD, University Medical Center Groningen, The University of Groningen, Groningen, The Netherlands.
Brian G G OliverRespiratory Cellular and Molecular Biology, Woolcock Institute of Medical Research, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-7122-9262
Maarten van den BergeGroningen Research Institute for Asthma and COPD, University Medical Center Groningen, The University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-9336-7340
Alen FaizRespiratory Bioinformatics and Molecular Biology, School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-1740-3538
University of Technology Sydney · AUUniversity Medical Center Groningen · NLUniversity of Michigan · USUtrecht University · NL

Funding

An Early Imaging Marker of EmphysemaR01HL139690 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GALBAN, CRAIG J · 2019 to 2022
$1.9M
NHLBI NIH HHS R01 HL139690
6 · The paper itself

Abstract

Parametric response mapping (PRM) is a computed tomography (CT)-based method to phenotype patients with chronic obstructive pulmonary disease (COPD). It is capable of differentiating emphysema-related air trapping with nonemphysematous air trapping (small airway disease), which helps to identify the extent and localization of the disease. Most studies evaluating the gene expression in smokers and COPD patients related this to spirometric measurements, but none have investigated the relationship with CT-based measurements of lung structure. The current study aimed to examine gene expression profiles of brushed bronchial epithelial cells in association with the PRM-defined CT-based measurements of emphysema (PRM

Indexed as

Gene Expression ProfilingImage Processing, Computer-AssistedTomography, X-Ray ComputedAgedBronchiFemaleForced Expiratory VolumeGene Expression RegulationHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructivePulmonary Emphysemabronchial brushescomputed tomography-based parametric response mappingCOPDemphysemagene expression

Identifiers

PMID32320267
PMCPMC7938773
OpenAlexW3017197215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.