Evidence map›Paper›PMID 32320144›Full record

Trial reportObesity (Silver Spring, Md.)2020

Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.

Look AHEAD Research Group, Ariana M Chao, Thomas A Wadden, Robert I Berkowitz, George Blackburn, Paula Bolin, Jeanne M Clark, Mace Coday, Jeffrey M Curtis, Linda M Delahanty and 33 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
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  11. Article
  12. Article
  13. Article
  14. Obesity Management in Adults: A Review.JAMA · 2023 · on this map
    Review
  15. Review
  16. Review
  17. Long-term weight change after a technology-based weight loss intervention.Journal of the American Geriatrics Society · 2023
    Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 1 country.

Look AHEAD Research Group
Ariana M ChaoDepartment of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-5633-8973
Thomas A WaddenDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0438-4609
Robert I BerkowitzDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
George BlackburnDivision of Nutrition, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Paula BolinSouthwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Jeanne M ClarkDivision of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Mace CodayDepartments of Preventive Medicine and Psychiatry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Jeffrey M CurtisSouthwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Linda M DelahantyDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Gareth R DuttonDivision of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mary EvansDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Linda J EwingDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John P ForeytDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Linda J GayDepartment of Psychiatry, The Miriam Hospital, Brown Medical School, Providence, Rhode Island, USA.
Edward W GreggDivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Helen P HazudaDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
James O HillAnschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Edward S HortonDepartment of Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, Massachusetts, USA.
Denise K HoustonDepartment of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA.ORCID 0000-0002-3355-4304
John M JakicicDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6800-9368
Robert W JefferyDivisions of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Karen C JohnsonDepartments of Preventive Medicine and Psychiatry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID 0000-0002-3493-4077
Steven E KahnDivision of Metabolism, Endocrinology and Nutrition, US Department of Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.
William C KnowlerSouthwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Anne KureDivision of Metabolism, Endocrinology and Nutrition, US Department of Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.
Katherine L MichalskiDivision of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Maria G MontezDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Rebecca H NeibergDepartment of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA.
Jennifer PatricioDepartment of Medicine, St. Luke's Roosevelt Hospital Center, Columbia University, New York, New York, USA.
Anne PetersDivision of Endocrinology, University of Southern California, Los Angeles, California, USA.
Xavier Pi-SunyerDepartment of Medicine, St. Luke's Roosevelt Hospital Center, Columbia University, New York, New York, USA.
Henry PownallDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
David ReboussinDepartment of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA.
Bruce RedmonDivisions of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
W Jack RejeskiDepartment of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA.ORCID 0000-0003-2281-4649
Helmut SteinburgDepartments of Preventive Medicine and Psychiatry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Martha WalkerDivision of Endocrinology, University of Southern California, Los Angeles, California, USA.
Donald A WilliamsonPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Rena R WingDepartment of Psychiatry, The Miriam Hospital, Brown Medical School, Providence, Rhode Island, USA.
Holly WyattAnschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Susan Z YanovskiDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Ping ZhangDivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Wake Forest University · USSt. Joseph's Hospital and Medical Center · USUniversity of Pennsylvania · USUniversity of Tennessee Health Science Center · USBaylor College of Medicine · USCenters for Disease Control and Prevention · USJohns Hopkins University · USNational Institute of Diabetes and Digestive and Kidney Diseases · USProvidence College · USSt. Luke's-Roosevelt Hospital Center · USThe University of Texas Health Science Center at San Antonio · USUnited States Department of Veterans Affairs · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Minnesota · USUniversity of Pittsburgh · USUniversity of Southern California · USBeth Israel Deaconess Medical Center · USJoslin Diabetes Center · USMassachusetts General Hospital · USPennington Biomedical Research Center · US

Funding

Look AHEAD: Action for Health in DiabetesU01DK057136 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW, WAGENKNECHT, LYNNE E · 1999 to 2020
$54.9M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill · 2000 to 2026
$31.9M
SHOW PROJECTU01DK057154 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NATHAN, DAVID M · 1999 to 2020
$23.1M
Look AHEAD: Action for Health DiabetesU01DK057178 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI LAFERRERE, BLANDINE B · 1999 to 2020
$21.2M
The Look AHEAD Continuation: Action for Health in DiabetesU01DK057078 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JOHNSON, KAREN C · 1999 to 2020
$20.1M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057135 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI WADDEN, THOMAS A. · 1999 to 2020
$20.0M
The Look AHEAD Continuation: Action for Health in DiabetesU01DK056992 · NIDDK · MIRIAM HOSPITAL · PI WING, RENA R · 1999 to 2020
$20.0M
Look AHEAD: Action for Health in Diabetes ContinuationU01DK057151 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CATENACCI, VICTORIA A · 1999 to 2020
$19.4M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW) TRIALU01DK057177 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FOREYT, JOHN P. · 1999 to 2020
$18.0M
Study of Health Outcomes of Weight Loss (Look AHEAD)U01DK057182 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JEFFERY, ROBERT W · 1999 to 2020
$17.9M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057002 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JAKICIC, JOHN M · 1999 to 2020
$17.9M
CDC HHSIndian Health ServiceNHLBI NIH HHSNIDDK NIH HHS DK56990NIDDK NIH HHS DK56992NIDDK NIH HHS DK57002NIDDK NIH HHS DK57008NIDDK NIH HHS DK57078NIDDK NIH HHS DK57131NIDDK NIH HHS DK57135NIDDK NIH HHS DK57136NIDDK NIH HHS DK57149NIDDK NIH HHS DK57151NIDDK NIH HHS DK57154NIDDK NIH HHS DK57171NIDDK NIH HHS DK57177NIDDK NIH HHS DK57178NIDDK NIH HHS DK57182NIDDK NIH HHS DK57219NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P30 DK111022NIDDK NIH HHS U01 DK056990NIDDK NIH HHS U01 DK056992NIDDK NIH HHS U01 DK057002NIDDK NIH HHS U01 DK057008NIDDK NIH HHS U01 DK057078NIDDK NIH HHS U01 DK057131NIDDK NIH HHS U01 DK057135NIDDK NIH HHS U01 DK057136NIDDK NIH HHS U01 DK057149NIDDK NIH HHS U01 DK057151NIDDK NIH HHS U01 DK057154NIDDK NIH HHS U01 DK057171NIDDK NIH HHS U01 DK057177NIDDK NIH HHS U01 DK057178NIDDK NIH HHS U01 DK057182NIDDK NIH HHS U01 DK057219NIMHD NIH HHSNINR NIH HHS K23 NR017209NINR NIH HHS K23NR017209Office of Research on Women's Health
6 · The paper itself

Abstract

objectiveThis study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group.

methodsLook AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012.

resultsTwo years after the end of the intervention (EOI), ILI and DSE participants lost a mean  (SE) of 1.2  (0.2) kg and 1.8  (0.2) kg, respectively (P = 0.003). In addition, 31% of ILI and 23.9% of DSE participants gained ≥ 2% (P < 0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost ≥ 2% of EOI weight (P = 0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants.

conclusionsBoth groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained ≥ 2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.

Indexed as

Life StyleAgedFemaleHumansMaleMiddle AgedObesityWeight Loss

Identifiers

PMID32320144
PMCPMC7437140
OpenAlexW3016710586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.