Trial reportThe American journal of clinical nutrition2020
How oro-sensory exposure and eating rate affect satiation and associated endocrine responses-a randomized trial.
Trial report in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Combination of Texture-Induced Oral Processing and Vegetable Preload Strategy Reduced Glycemic Excursion but Decreased Insulin Sensitivity.Nutrients · 2022Trial
- Development and Validation of the Food Consumption Rate Questionnaire (FCRQ): A Behaviorally Informed Measure of Eating-Rate Regulation.Nutrients · 2026Article
- Influence of natural variations in eating rate and bolus properties on postprandial glucose and insulin responses in healthy adults.European journal of nutrition · 2026Article
- Enhancing Nutritional Ingestive Behavior Microstructure Detection: Video Annotation and Passive Sensing Approaches.Nutrients · 2026Article
- Predicting Satiety from the Analysis of Human Saliva Using Mid-Infrared Spectroscopy Combined with Chemometrics.Foods (Basel, Switzerland) · 2022Article
- Integrating Effects of Human Physiology, Psychology, and Individual Variations on Satiety-An Exploratory Study.Frontiers in nutrition · 2022Article
- Influence of Sensory Properties in Moderating Eating Behaviors and Food Intake.Frontiers in nutrition · 2022Review
- Cephalic phase insulin release: A review of its mechanistic basis and variability in humans.Physiology & behavior · 2021Review
- Increased oral processing and a slower eating rate increase glycaemic, insulin and satiety responses to a mixed meal tolerance test.European journal of nutrition · 2021Article
- The Satiation Framework: Exploring processes that contribute to satiation.Physiology & behavior · 2021Article
- Effects of Oro-Sensory Exposure on Satiation and Underlying Neurophysiological Mechanisms-What Do We Know So Far?Nutrients · 2021Review
- Impact of food texture modifications on oral processing behaviour, bolus properties and postprandial glucose responses.Current research in food science · 2021Article
- Oral Health and Nutritional Characteristics of Adults With Morbid Obesity: A Multivariate Analysis.Frontiers in nutrition · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLonger oral processing decreases food intake. This can be attributed to greater oro-sensory exposure (OSE) and a lower eating rate (ER). How these factors contribute to food intake, and the underlying physiological mechanisms, remain unclear.
objectivesWe aimed to determine the independent and simultaneous effects of OSE and ER on satiation and associated endocrine responses.
methodsForty participants in study 1 [mean ± SD age: 24 ± 4 y; BMI (in kg/m2): 22 ± 2] and 20 in study 2 (mean ± SD age: 23 ± 3 y; BMI: 23 ± 2) participated in a 2 × 2 randomized trial. In both studies, participants ate chocolate custard with added caramel sauce (low OSE) or caramel fudge (high OSE) and with short (fast ER) or long breaks (slow ER) in between bites, until fullness. In study 2, endocrine responses were measured during the meal.
resultsIn study 1, participants ate (mean ± SEM) 42 ± 15 g less in the slow- than in the fast-ER condition, only within the high-OSE condition (P = 0.04). In study 2, participants ate 66 ± 21 g less in the high- than in the low-OSE condition and there were no intake differences between slow and fast ER (P = 0.35). Eight minutes after starting to eat, insulin concentrations increased by 42%-65% in all treatments compared with the control. At the end of the meal, insulin concentrations were 81% higher in the high-OSE, slow-ER than in the low-OSE, fast-ER condition (P = 0.049). Pancreatic polypeptide (PP) increased by 62%, 5 min after meal onset in the low-OSE, fast-ER condition (P = 0.005). Ghrelin concentrations did not change.
conclusionsGreater OSE increases insulin responsiveness. In contrast, PP responses are stronger when OSE is reduced and ER is fast. Insulin and PP responses may mediate the independent effects of OSE and ER on food intake. These may be beneficial eating strategies, particularly for type 2 diabetic patients, to control food intake and maintain glucose homeostasis.This trial was registered at trialregister.nl as NL6544.
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