ArticleeLife2020
Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Alternative Polyadenylation in the Brain is Modulated by Chronic Ethanol Exposure in a Sex- and Cell Type-Specific Manner.Molecular neurobiology · 2026Article
- Nanopore full-length sequencing reveals Nudt21 knockdown drives genome-wide 3'UTR shortening and transcriptome reprogramming in mouse hepatocytes.BMC genomics · 2026Article
- Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration.Nature communications · 2026Article
- Alternative cleavage and polyadenylation: key regulatory mechanisms in health and disease.RNA biology · 2025Review
- Characterization and molecular targeting of CFIm25 (NUDT21/CPSF5) mRNA using miRNAs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation.Frontiers in molecular neuroscience · 2025Article
- PolyAMiner-Bulk is a deep learning-based algorithm that decodes alternative polyadenylation dynamics from bulk RNA-seq data.Cell reports methods · 2024Article
- NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1.Journal of neuro-oncology · 2023Article
- Alternative polyadenylation alters protein dosage by switching between intronic and 3'UTR sites.Science advances · 2023Article
- RNAseq Analysis of FABP4 Knockout Mouse Hippocampal Transcriptome Suggests a Role for WNT/β-Catenin in Preventing Obesity-Induced Cognitive Impairment.International journal of molecular sciences · 2023Article
- NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2.Open life sciences · 2023Article
- Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration.Neuron · 2022Article
- Regulation of the Alternative Neural Transcriptome by ELAV/Hu RNA Binding Proteins.Frontiers in genetics · 2022Review
- Emerging roles of alternative cleavage and polyadenylation (APA) in human disease.Journal of cellular physiology · 2022Review
- Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons.eLife · 2021Article
- A computational pipeline to infer alternative poly-adenylation from 3' sequencing data.Methods in enzymology · 2021Article
- A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3' end processing is associated with intellectual disability in humans.Nucleic acids research · 2020Article
- PolyA-miner: accurate assessment of differential alternative poly-adenylation from 3'Seq data using vector projections and non-negative matrix factorization.Nucleic acids research · 2020Article
- Emerging Roles for 3' UTRs in Neurons.International journal of molecular sciences · 2020Review
- Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation.eLife · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 2 countries.
Callison E AlcottProgram in Developmental Biology, Baylor College of Medicine, Houston, United States.ORCID 0000-0003-4166-5634
Hari Krishna YalamanchiliJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Ping JiDepartment of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Meike E van der HeijdenJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.ORCID 0000-0003-0801-8806
Alexander SaltzmanVerna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, United States.ORCID 0000-0003-4166-9555
Nathan ElrodDepartment of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, United States.ORCID 0000-0003-1310-6026
Ai LinDepartment of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Mei LengVerna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, United States.
Bhoomi BhattVerna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, United States.
Shuang HaoJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Qi WangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Afaf SalibaJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Jianrong TangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Anna MalovannayaVerna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, United States.
Eric J WagnerDepartment of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Zhandong LiuJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Huda Y ZoghbiProgram in Developmental Biology, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-0700-3349
Baylor College of Medicine · USThe University of Texas Medical Branch at Galveston · USChinese Academy of Medical Sciences & Peking Union Medical College · CN
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8MProbing the specificity and activity of the metazoan Integrator complexR01GM134539 · NIGMS · HARVARD MEDICAL SCHOOL · PI Karen L Adelman, ERIC J WAGNER · 2019 to 2026
$4.7MCharacterization of Ras/Akt/CFIm25/APA signaling in Glioblastoma Development and ProgressionR03CA223893 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI JI, PING · 2018 to 2019
$158kThe role of Nudt21 in MeCP2 regulation and neuropsychiatric diseaseF30NS095449 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ALCOTT, CALLISON EDWARD · 2016 to 2018
$127kNCI NIH HHS P30 CA125123NCI NIH HHS R03 CA223893NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIGMS NIH HHS R01 GM134539NINDS NIH HHS F30 NS095449
Abstract
We previously showed that
Indexed as
PolyadenylationAnimalsCells, CulturedCleavage And Polyadenylation Specificity FactorDNA Copy Number VariationsFemaleGene Expression RegulationHippocampusHumansLearning DisabilitiesMaleMice, Inbred C57BLNeuronsCleavage And Polyadenylation Specificity FactorNudt21 protein, humanNudt21 protein, mousealternative polyadenylationCFIm25gene regulationgeneticsgenomicshumanintellectual disabilitylearning deficitsmouseneuroscienceNUDT21
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.