Evidence map›Paper›PMID 32319642›Full record

ArticleMolecular medicine reports2020

MicroRNA‑93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarctionω.

Chengjie Ma, Peipei Peng, Yan Zhou, Tianya Liu, Lijuan Wang, Chen Lu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Targeting the Hippo pathway in heart repair.Cardiovascular research · 2022
    Review
  7. Signaling pathways and targeted therapy for myocardial infarction.Signal transduction and targeted therapy · 2022
    Review
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chengjie Ma *Clinical and Research Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China.
Peipei Peng *Department of Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Yan ZhouDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.
Tianya LiuJiangsu Province Key Laboratory of Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.
Lijuan WangJiangsu Province Key Laboratory of Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.
Chen LuJiangsu Province Key Laboratory of Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.
Xuzhou Medical College · CNBeijing Ditan Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inactivation of the Hippo pathway protects the myocardium from cardiac ischemic injury. MicroRNAs (miRs) have been reported to play pivotal roles in the progression of myocardial infarction (MI). The present study examined whether miR‑93 could promote angiogenesis and attenuate remodeling after MI via inactivation of the Hippo/Yes‑associated protein (Yap) pathway, by targeting large tumor suppressor kinase 2 (Lats2). It was identified that transfection of human umbilical vein endothelial cells with miR‑93 mimic significantly decreased Lats2 expression and Yap phosphorylation, increased cell viability and migration, and attenuated cell apoptosis following hypoxia/reoxygenation injury. Moreover, increased expression of miR‑93 resulted in an improvement of cardiac function, promotion of angiogenesis and attenuation of remodeling after MI. Additionally, miR‑93 overexpression significantly decreased intracellular adhesion molecule 1 and vascular cell adhesion protein 1 expression levels, as well as attenuated the infiltration of neutrophils and macrophages into the myocardium after MI. Furthermore, it was found that miR‑93 overexpression significantly suppressed Lats2 expression and decreased the levels of phosphorylated Yap in the myocardium after MI. Collectively, the present results suggested that miR‑93 may exert a protective effect against MI via inactivation of the Hippo/Yap pathway by targeting Lats2.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsGene Expression RegulationHippo Signaling PathwayHumansHuman Umbilical Vein Endothelial CellsMiceMicroRNAsMyocardial InfarctionNeovascularization, PhysiologicProtein Serine-Threonine KinasesSignal TransductionTumor Suppressor ProteinsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsLATS2 protein, mouseMicroRNAsMirn93 microRNA, mouseProtein Serine-Threonine KinasesTumor Suppressor ProteinsYap1 protein, mouseYAP-Signaling ProteinsangiogenesisHippo/Yes-associated protein pathwaylarge tumor suppressor kinase 2microrna-93myocardial infarction

Identifiers

PMID32319642
PMCPMC7248469
OpenAlexW3016962338

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.