Evidence map›Paper›PMID 32319596›Full record

ArticleInternational journal of oncology2020

Advances in circular RNAs and their role in glioma (Review).

Yuhao Zhang, Xiaomeng Lin, Xiuchao Geng, Liang Shi, Qiang Li, Fulin Liu, Chuan Fang, Hong Wang

Abstract read
In one paragraph

Article in International journal of oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuhao Zhang *Hebei University, School of Medicine, Baoding, Hebei 071000, P.R. China.
Xiaomeng Lin *Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
Xiuchao GengHebei University of Chinese Medicine, Faculty of Integrated Traditional Chinese and Western Medicine, Shijiazhuang, Hebei 050091, P.R. China.
Liang ShiHebei University, School of Medicine, Baoding, Hebei 071000, P.R. China.
Qiang LiHebei University of Chinese Medicine, Faculty of Acupuncture‑Moxibustion and Tuina, Shijiazhuang, Hebei 050200, P.R. China.
Fulin LiuOffice of Academic Research, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
Chuan FangDepartment of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
Hong WangHebei University, School of Medicine, Baoding, Hebei 071000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma is the most common primary tumour of the central nervous system, and is associated with a high postoperative recurrence rate and resistance to chemotherapy. High‑grade glioblastoma in particular has a very poor prognosis and poses a serious threat to human health. Related studies have confirmed that the occurrence and development of gliomas are closely associated with the abnormal expression and regulation of genes. Moreover, the number of studies on the association of the expression of non‑coding RNAs [linear RNAs, microRNAs and circular RNAs (circRNAs)] in human cells with glioma has been gradually increasing in recent years. Among those, circRNAs, previously considered to be 'splicing errors', have been shown to be highly expressed in eukaryotic cells and regulate the biological behaviour of gliomas. circRNAs are highly abundant and stable, and have become a research hotspot in the field of glioma molecular biology. The aim of the present review was to focus on the research progress regarding the association between circRNA expression and gliomas, and to provide a theoretical basis according to the currently available literature for further exploring this association. The present study may be of value for the early diagnosis, pathological grading, targeted therapy and prognostic evaluation of gliomas.

Indexed as

Gene Expression Regulation, NeoplasticAntineoplastic AgentsBiomarkers, TumorBrainBrain NeoplasmsCarcinogenesisDrug Resistance, NeoplasmEarly Detection of CancerGenetic TherapyGliomaHumansMolecular Targeted TherapyNeoplasm GradingNeoplasm Recurrence, LocalPrognosisRNA, CircularAntineoplastic AgentsBiomarkers, TumorRNA, Circularbiomarkercentral nervous systemcircular RNAscorrelationfunctiongene therapyglioblastomagliomamechanismresearch progress

Identifiers

PMID32319596
PMCPMC7252450

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.