ArticleInternational journal of oncology2020
Identification of the cis‑molecular neighbours of the immune checkpoint protein B7‑H4 in the breast cancer cell‑line SK‑BR‑3 by proteomic proximity labelling.
Article in International journal of oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Exploring B7-H4's Role in Prostate Cancer Dormancy after Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities.Molecular cancer research : MCR · 2025Article
- Review
- Astragaloside IV Regulates cGAS-STING Signaling Pathway to Alleviate Immunosuppression Caused by PRRSV Infection.Viruses · 2023Article
- Radius measurement via super-resolution microscopy enables the development of a variable radii proximity labeling platform.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Proteomic analysis in primary T cells reveals IL-7 alters T cell receptor thresholding via CYTIP/cytohesin/LFA-1 localisation and activation.The Biochemical journal · 2022Article
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Authors and funding
8 authors.
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Abstract
The immune checkpoint protein B7‑H4 plays an important role in the positive as well as the negative regulation of immune T‑cell responses. When expressed on cancer cells, B7‑H4 inhibits T‑cell activity, and numerous types of cancer cells use upregulation of B7‑H4 as a survival strategy. Thus, B7‑H4 is a potential target for anticancer drug therapy. Unfortunately, the cell biology of this molecule has yet to be fully elucidated. Even basic properties, such as the nature of B7‑H4 interactors, are controversial. In particular, the cis‑interactors of B7‑H4 on cancer cell plasma membranes have not been investigated to date. The present study used a proteomic proximity‑labelling assay to investigate the molecular neighbours of B7‑H4 on the surface of the human breast cancer cells SK‑BR‑3. By comparison to a comprehensive proteome analysis of SK‑BR‑3 cells, the proximity method detected a relatively small number of low abundance plasma membrane proteins highly enriched for proteins known to modulate cell adhesion and immune recognition. It may be inferred that these molecules contribute to the immunosuppressive behaviour that is characteristic of B7‑H4 on cancer cells.
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