Evidence map›Paper›PMID 32319524›Full record

ArticleThe Journal of infectious diseases2022

Insights Into Pneumococcal Pneumonia Using Lung Aspirates and Nasopharyngeal Swabs Collected From Pneumonia Patients in The Gambia.

Eileen M Dunne, Yinglei Hua, Rasheed Salaudeen, Ilias Hossain, Malick Ndiaye, Belinda D Ortika, E Kim Mulholland, Jason Hinds, Sam Manna, Grant A Mackenzie and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Eileen M DunneInfection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
Yinglei HuaInfection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
Rasheed SalaudeenMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Ilias HossainMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Malick NdiayeMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Belinda D OrtikaInfection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
E Kim MulhollandInfection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
Jason HindsInstitute for Infection and Immunity, St. George's University of London, London, United Kingdom.
Sam MannaInfection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
Grant A MackenzieInfection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
Catherine SatzkeInfection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.ORCID 0000-0003-3164-8849
The University of Melbourne · AUMRC Unit the Gambia · GMMurdoch Children's Research Institute · AUSt George's, University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the pathogenesis of pneumococcal pneumonia using clinical specimens collected for pneumonia surveillance in The Gambia.

methodsLung aspirates and nasopharyngeal swabs from 31 patients were examined by culture, quantitative polymerase chain reaction (qPCR), whole genome sequencing, serotyping, and reverse-transcription qPCR.

resultsFive lung aspirates cultured pneumococci, with a matching strain identified in the nasopharynx. Three virulence genes including ply (pneumolysin) were upregulated >20-fold in the lung compared with the nasopharynx. Nasopharyngeal pneumococcal density was higher in pediatric pneumonia patients compared with controls (P < .0001).

conclusionsFindings suggest that changes in pneumococcal gene expression occurring in the lung environment may be important in pathogenesis.

Indexed as

Pneumococcal InfectionsPneumonia, PneumococcalChildGambiaHumansLungNasopharynxStreptococcus pneumoniaelungnasopharynxpneumococcuspneumoniaStreptococcus pneumoniae

Identifiers

PMID32319524
PMCPMC9016440
OpenAlexW3016539529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.