Evidence map›Paper›PMID 32319523›Full record

ArticleNucleic acids research2020

miRViz: a novel webserver application to visualize and interpret microRNA datasets.

Pierre Giroux, Ricky Bhajun, Stéphane Segard, Claire Picquenot, Céline Charavay, Lise Desquilles, Guillaume Pinna, Christophe Ginestier, Josiane Denis, Nadia Cherradi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Construction and Analysis of miRNA Regulatory Networks.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  2. Trials and Tribulations of MicroRNA Therapeutics.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Pierre GirouxUniv. Grenoble Alpes, CEA, IRIG, Inserm, BCI, 38000 Grenoble, France.
Ricky BhajunUniv. Grenoble Alpes, CEA, IRIG, Inserm, BGE, 38000 Grenoble, France.
Stéphane SegardUniv. Grenoble Alpes, CEA, IRIG, Inserm, BGE, 38000 Grenoble, France.
Claire PicquenotUniv. Grenoble Alpes, CEA, IRIG, Inserm, BGE, 38000 Grenoble, France.
Céline CharavayUniv. Grenoble Alpes, CEA, IRIG, Inserm, BGE, 38000 Grenoble, France.
Lise DesquillesUniv. Grenoble Alpes, CEA, IRIG, Inserm, BCI, 38000 Grenoble, France.
Guillaume PinnaInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, University Paris-Sud, University Paris-Saclay, F-91191 Gif-sur-Yvette, France.
Christophe GinestierAix-Marseille Université, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Epithelial Stem Cells and Cancer lab, F-13273 Marseille, France.
Josiane DenisUniv. Grenoble Alpes, CEA, IRIG, Inserm, BCI, 38000 Grenoble, France.
Nadia CherradiUniv. Grenoble Alpes, CEA, IRIG, Inserm, BCI, 38000 Grenoble, France.
Laurent GuyonUniv. Grenoble Alpes, CEA, IRIG, Inserm, BCI, 38000 Grenoble, France.
Inserm · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that are involved in the regulation of major pathways in eukaryotic cells through their binding to and repression of multiple mRNAs. With high-throughput methodologies, various outcomes can be measured that produce long lists of miRNAs that are often difficult to interpret. A common question is: after differential expression or phenotypic screening of miRNA mimics, which miRNA should be chosen for further investigation? Here, we present miRViz (http://mirviz.prabi.fr/), a webserver application designed to visualize and interpret large miRNA datasets, with no need for programming skills. MiRViz has two main goals: (i) to help biologists to raise data-driven hypotheses and (ii) to share miRNA datasets in a straightforward way through publishable quality data representation, with emphasis on relevant groups of miRNAs. MiRViz can currently handle datasets from 11 eukaryotic species. We present real-case applications of miRViz, and provide both datasets and procedures to reproduce the corresponding figures. MiRViz offers rapid identification of miRNA families, as demonstrated here for the miRNA-320 family, which is significantly exported in exosomes of colon cancer cells. We also visually highlight a group of miRNAs associated with pluripotency that is particularly active in control of a breast cancer stem-cell population in culture.

Indexed as

SoftwareAdrenal Cortex NeoplasmsAdrenocortical CarcinomaAnimalsBreast NeoplasmsColonic NeoplasmsDatasets as TopicExosomesFemaleHumansInternetMiceMicroRNAsNeoplastic Stem CellsMicroRNAs

Identifiers

PMID32319523
PMCPMC7319447
OpenAlexW3016362707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.