ReviewMedical science monitor : international medical journal of experimental and clinical research2020
Progress in Research on Sperm DNA Fragmentation.
Review in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Effect of sperm DNA fragmentation on embryo euploidy rate in assisted reproductive technologies: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research.International journal of molecular sciences · 2021Pooled it
- Simultaneous LC-MS/MS quantification of free deoxyguanosines 2'-dG and 8-OHdG in ovine seminal plasma as biomarkers of oxidative DNA damage.Frontiers in medicine · 2026Article
- Expert-Annotated Optical Microscopy Images of Human Sperm for Detection and DNA Fragmentation Assessment.Scientific data · 2025Article
- Relationship Between Sperm Parameters and Indices of Chromatin Condensation and DNA Fragmentation in Semen.Biology · 2025Article
- Parental Characteristics Associated With Children Born With Neural Tube Defects in Puebla, Mexico.Cureus · 2025Article
- Association of sperm DNA fragmentation with higher miscarriage rates in non-male factor infertility reproductive cycles.Translational andrology and urology · 2025Article
- Article
- Perspective in the Mechanisms for Repairing Sperm DNA Damage.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Paternal Contributions to Recurrent Pregnancy Loss: Mechanisms, Biomarkers, and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- Male Reproductive Toxicity of Antifouling Chemicals: Insights into Oxidative Stress-Induced Infertility and Molecular Mechanisms of Zinc Pyrithione (ZPT).Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Canine sperm motility is associated with telomere shortening and changes in expression of shelterin genes.BMC veterinary research · 2023Article
- Oxidative Stress and Male Infertility: The Protective Role of Antioxidants.Medicina (Kaunas, Lithuania) · 2023Review
- The effects of hormonal changes on sperm DNA integrity in oligoasthenoteratospermia individuals: A case-control study.International journal of reproductive biomedicine · 2022Article
- Repair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in mice.Pharmaceutical biology · 2022Article
- The association between serum estradiol levels and sperm DNA integrity.Environmental and molecular mutagenesis · 2022Article
- Effect of Chronic Moderate Caloric Restriction on the Reproductive Function in Aged Male Wistar Rats.Nutrients · 2022Article
- Sperm DNA fragmentation and male fertility: a retrospective study of 5114 men attending a reproductive center.Journal of assisted reproduction and genetics · 2021Article
- The Necessity to Retrieve Testicular Sperm in Infertile Non-Azoospermic Men with High Levels of SDF.Journal of reproduction & infertilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the increasing incidence of male infertility, routine detection of semen is insufficient to accurately assess male fertility. Infertile men, who have lower odds of conceiving naturally, exhibit high levels of sperm DNA fragmentation (SDF). The mechanisms driving SDF include abnormal spermatogenesis, oxidative stress damage, and abnormal sperm apoptosis. As these factors can induce SDF and subsequent radical changes leading to male infertility, detection of the extent of SDF has become an efficient routine method for semen analysis. Although it is still debated, SDF detection has become a research hotspot in the field of reproductive medicine as a more accurate indicator for assessing sperm quality and male fertility. SDF may be involved in male infertility, reproductive assisted outcomes, and growth and development of offspring. The effective detection methods of SDF are sperm chromatin structure analysis (SCSA), terminal transferase-mediated dUTP end labeling (TUNEL) assay, single-cell gel electrophoresis (SCGE) assay, and sperm chromatin dispersion (SCD) test, and all of these methods are valuable for assisted reproductive techniques. Currently, the preferred method for detecting sperm DNA integrity is SCSA. However, the regulation network of SDF is very complex because the sperm DNA differs from the somatic cell DNA with its unique structure. A multitude of molecular factors, including coding genes, non-coding genes, or methylated DNA, participate in the complex physiological regulation activities associated with SDF. Studying SDF occurrence and the underlying mechanisms may effectively improve its clinical treatments. This review aimed to outline the research status of SDF mechanism and detection technology-related issues, as well as the effect of increased SDF rate, aiming to provide a basis for clinical male infertility diagnosis and treatment.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.