ReviewThe American journal of tropical medicine and hygiene2020
Respiratory Support in COVID-19 Patients, with a Focus on Resource-Limited Settings.
Review in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05083130 (Evaluation of Awake Prone Positioning Effectiveness in Moderate to Severe COVID-19), which is not on this map. Cited by 94 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Awake Prone Positioning Effectiveness in Moderate to Severe COVID-19
Who cites it
94 citing papers in PubMed, 4 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- Perioperative oxygen therapy in patients undergoing surgical procedures: an overview of systematic reviews and meta-analyses.Health technology assessment (Winchester, England) · 2025Pooled it
- Effects of pulmonary air leak on patients with coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis.BMC pulmonary medicine · 2023Pooled it
- Intubation rate of patients with hypoxia due to COVID-19 treated with awake proning: A meta-analysis.The American journal of emergency medicine · 2021Pooled it
- COVID-19 ICU and mechanical ventilation patient characteristics and outcomes-A systematic review and meta-analysis.PloS one · 2021Pooled it
- Minimizing Societal Cost of Epidemics: Optimal Catastrophe Insurance Compensation Allocation.Risk analysis : an official publication of the Society for Risk Analysis · 2026Article
- SARS-CoV-2 Pneumonia: Advances in Diagnosis and Treatment.Microorganisms · 2025Review
- A prospective study of the effect of COVID-19 on psychiatric symptoms and sleep problems from infection to 9-month follow-up.European archives of psychiatry and clinical neuroscience · 2025Article
- Addressing data quality issues to assess clinical and epidemiological risk factors for COVID-19 among documented cases in Liberia: a single-centre, retrospective, observational study.BMJ public health · 2024Article
- Clinical characterisation, treatment outcomes, and case fatality risk of patients with different SARS-CoV-2 variants in Bangladesh.Journal of global health · 2024Observational
- An AI-based multiphase framework for improving the mechanical ventilation availability in emergency departments during respiratory disease seasons: a case study.International journal of emergency medicine · 2024Article
- Tele-monitoring system for intensive care ventilators in isolation rooms.Scientific reports · 2023Article
- Development and assessment of the performance of a shared ventilatory system that uses clinically available components to individualize tidal volumes.BMC anesthesiology · 2023Article
- Enteral liquid ventilation oxygenates a hypoxic pig model.iScience · 2023Article
- A Novel Approach to Repair of Tracheal Occlusion Secondary to Percutaneous Tracheostomy Creation.Cureus · 2023Article
- High-Flow Nasal Cannula oxygen therapy in COVID-19: retrospective analysis of clinical outcomes - single center experience.Frontiers in medicine · 2023Article
- Outcomes of Invasive and Noninvasive Ventilation in a Haitian Emergency Department.Annals of global health · 2023Observational
- What did we learn about tocilizumab use against COVID-19? A single-center observational study from an intensive care unit in Serbia.Frontiers in medicine · 2023Article
- Financial Implications of Tariffs for Medical Oxygen on Rwandan Public Hospitals' Finance Management During the Coronavirus Epidemic.Global health, science and practice · 2022Article
- Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study.Critical care (London, England) · 2022Observational
- Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ongoing novel coronavirus disease (COVID-19) pandemic is threatening the global human population, including in countries with resource-limited health facilities. Severe bilateral pneumonia is the main feature of severe COVID-19, and adequate ventilatory support is crucial for patient survival. Although our knowledge of the disease is still rapidly increasing, this review summarizes current guidance on the best provision of ventilatory support, with a focus on resource-limited settings. Key messages include that supplemental oxygen is a first essential step for the treatment of severe COVID-19 patients with hypoxemia and should be a primary focus in resource-limited settings where capacity for invasive ventilation is limited. Oxygen delivery can be increased by using a non-rebreathing mask and prone positioning. The presence of only hypoxemia should in general not trigger intubation because hypoxemia is often remarkably well tolerated. Patients with fatigue and at risk for exhaustion, because of respiratory distress, will require invasive ventilation. In these patients, lung protective ventilation is essential. Severe pneumonia in COVID-19 differs in some important aspects from other causes of severe pneumonia or acute respiratory distress syndrome, and limiting the positive end-expiratory pressure level on the ventilator may be important. This ventilation strategy might reduce the currently very high case fatality rate of more than 50% in invasively ventilated COVID-19 patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.